SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.
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SIRT2 as a Therapeutic Target for Age-Related DisordersThe histone deacetylase SIRT2 stabilizes Myc oncoproteinsThe tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylationImmunogenicity and Safety of an EB66 Cell-Culture-Derived Influenza A/Indonesia/5/2005(H5N1) AS03-Adjuvanted Vaccine: A Phase 1 Randomized Trial.Correlation Between the Interval of Influenza Virus Infectivity and Results of Diagnostic Assays in a Ferret Model.A Novel Vaccination Strategy Mediating the Induction of Lung-Resident Memory CD8 T Cells Confers Heterosubtypic Immunity against Future Pandemic Influenza VirusRejuvenating sirtuins: the rise of a new family of cancer drug targetsNovel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cellsCross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.Sorting out functions of sirtuins in cancerActivation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell.The association of receptor of activated protein kinase C 1(RACK1) with infectious bursal disease virus viral protein VP5 and voltage-dependent anion channel 2 (VDAC2) inhibits apoptosis and enhances viral replication.Viral suppression function of intracellular antibody against C-terminal domain of rabies virus phosphoprotein.The orally bioavailable MDM2 antagonist RG7112 and pegylated interferon α 2a target JAK2V617F-positive progenitor and stem cells.Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivoImpact of Adjuvants on the Immunogenicity and Efficacy of Split-Virion H7N9 Vaccine in Ferrets.SIRT2 plays a significant role in maintaining the survival and energy metabolism of PIEC endothelial cells.Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblastsCombination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cellsA Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients.Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress.Intracellular antibody receptor TRIM21 prevents fatal viral infection.An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury.Evaluation of benzoic acid derivatives as sirtuin inhibitors.The dual role of sirtuins in cancer.Sirtuins in stress response: guardians of the genome.The diversity of histone versus nonhistone sirtuin substrates.Sirtuin inhibitors as anticancer agents.Anticancer agents targeted to sirtuins.The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.cAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung cancer cells.The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
P2860
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P2860
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@en
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@nl
type
label
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@en
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@nl
prefLabel
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@en
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@nl
P2093
P2860
P1433
P1476
SIRT2 down-regulation in HeLa ...... entually leading to apoptosis.
@en
P2093
Akihiro Kurimasa
Haruka Matsumori
Hirotada Kojima
Mitsuhiko Osaki
Mitsuo Oshimura
Motonobu Katoh
Seiichi Mori
Toshiaki Inoue
P2860
P356
10.1111/J.1365-2443.2010.01460.X
P577
2010-11-09T00:00:00Z