Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. - Wikidata - awgldk - TriplyDB

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.

http://www.wikidata.org/entity/Q39661595

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The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease The role of tau in neurodegenerative diseases and its potential as a therapeutic target Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Spreading of pathology in neurodegenerative diseases: a focus on human studies Alpha-synuclein spreading in Parkinson's disease Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases Amyloid oligomer neurotoxicity, calcium dysregulation, and lipid rafts Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins Alzheimer disease: a tale of two prions Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Acetylation: a new key to unlock tau's role in neurodegeneration Single mutations in tau modulate the populations of fibril conformers through seed selection.Pathological alpha-synuclein propagates through neural networks Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles.Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.The many faces of α-synuclein: from structure and toxicity to therapeutic target.Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.Alpha-synuclein transfers from neurons to oligodendrocytes.Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.Cross-seeding and conformational selection between three- and four-repeat human Tau proteins.Prion-like spread of protein aggregates in neurodegeneration Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells.Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau.Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

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Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.

http://www.wikidata.org/entity/Q39661595

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2010 nî lūn-bûn

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2010年論文

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2010年论文

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2010年论文

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name

Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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JBC.M110.148460

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Journal of Biological Chemistry

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Seeded aggregation and toxicit ...... of neurodegenerative diseases.

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Masato Hasegawa

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Sayuri T Watanabe

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Takeshi Iwatsubo

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

Transmission and spreading of tauopathy in transgenic mouse brain

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Neuropathological stageing of Alzheimer-related changes

Protein misfolding, functional amyloid, and human disease

Shattuck lecture--neurodegenerative diseases and prions

Impairment of the ubiquitin-proteasome system by protein aggregation

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

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34885-34898

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2010-08-30T00:00:00Z

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neurodegeneration

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