Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner
about
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosisReverse engineering of the spindle assembly checkpointConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointThe APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stabilityStructural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template modelDefining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 InhibitionBub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalingMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointIn-silico modeling of the mitotic spindle assembly checkpointDNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere.Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stabilitySystematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshinDisruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeastInositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes.The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint functionThe spindle checkpoint, aneuploidy, and cancer.Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progressionSim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.General aspects of colorectal cancerA NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Centrosomes and checkpoints: the MPS1 family of kinases.The spindle checkpoint: structural insights into dynamic signalling.Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1.Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation.Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint ArrestsEssential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exitBubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation.An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeastState of the APC/C: organization, function, and structure.Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3.
P2860
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P2860
Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年論文
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2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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2002年论文
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name
Fission yeast Mad3p is require ...... p-, and Mph1p-dependent manner
@en
Fission yeast Mad3p is require ...... -, and Mph1p-dependent manner.
@nl
type
label
Fission yeast Mad3p is require ...... p-, and Mph1p-dependent manner
@en
Fission yeast Mad3p is require ...... -, and Mph1p-dependent manner.
@nl
prefLabel
Fission yeast Mad3p is require ...... p-, and Mph1p-dependent manner
@en
Fission yeast Mad3p is require ...... -, and Mph1p-dependent manner.
@nl
P2860
P1476
Fission yeast Mad3p is require ...... p-, and Mph1p-dependent manner
@en
P2093
David N Millband
P2860
P304
P356
10.1128/MCB.22.8.2728-2742.2002
P407
P577
2002-04-01T00:00:00Z