Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. - Wikidata - awgldk - TriplyDB

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

http://www.wikidata.org/entity/Q39675800

about

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells Mitochondrial Stat3, the Need for Design Thinking The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression Pivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved Issues Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain Comparative evolutionary genomics of the STAT family of transcription factors Engaged for survival: From cadherin ligation to STAT3 activation Non-genomic STAT5-dependent effects at the endoplasmic reticulum and Golgi apparatus and STAT6-GFP in mitochondria Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging Mitochondrial STAT3 and reactive oxygen species: A fulcrum of adipogenesis?PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3 Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice STAT3 negatively regulates thyroid tumorigenesis MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.Signal integration and gene induction by a functionally distinct STAT3 phosphoform.A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance Regulation and function of signal transducer and activator of transcription 3.Novel method of monitoring trace cytokines and activated STAT molecules in the paws of arthritic mice using multiplex bead technology.Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction Erythropoietin signaling regulates heme biosynthesis.STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma.HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop.

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P2860

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

http://www.wikidata.org/entity/Q39675800

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

@zh-tw

2009年论文

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2009年论文

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2009年论文

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name

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@en

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@nl

type

label

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@en

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@nl

prefLabel

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@en

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

@nl

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SCIENCE.1171721

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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation

@en

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Alicia Corlett

http://www.w3.org/2001/XMLSchema#string

Andrew C Larner

http://www.w3.org/2001/XMLSchema#string

Joanna Wegrzyn

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Karni Schlessinger

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P2860

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

On the Origin of Cancer Cells

New and old functions of STAT3: a pivotal target for individualized treatment of cancer

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Stats: transcriptional control and biological impact

Stat3 as an oncogene

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization.

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10.1126/SCIENCE.1171721

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