Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine. - Wikidata - awgldk - TriplyDB

Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine.

Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine.

http://www.wikidata.org/entity/Q39681923

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The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene Role of CTCF protein in regulating FMR1 locus transcription Improved methodology for assessment of mRNA levels in blood of patients with FMR1 related disorders Methylation of novel markers of fragile X alleles is inversely correlated with FMRP expression and FMR1 activation ratio.In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents.FMR1 intron 1 methylation predicts FMRP expression in blood of female carriers of expanded FMR1 alleles.The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription Trinucleotide expansion in disease: why is there a length threshold?Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers.An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene Bromodomain inhibitors regulate the C9ORF72 locus in ALS Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.Elevated Fmr1 mRNA levels and reduced protein expression in a mouse model with an unmethylated Fragile X full mutation.Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche.Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells.Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia.Bidirectional transcription of trinucleotide repeats: roles for excision repair.FMR1: a gene with three faces.Methotrexate treatment of FraX fibroblasts results in FMR1 transcription but not in detectable FMR1 protein levels.A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome.Epigenetic changes and non-coding expanded repeats.The finger of an angel: memory return with epigenetic manipulation.The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.Molecular medicine of fragile X syndrome: based on known molecular mechanisms.Human pluripotent stem cell models of Fragile X syndrome.The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.Defining the role of the CGGBP1 protein in FMR1 gene expression.Human pluripotent stem cells in modeling human disorders: the case of fragile X syndrome.Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells.Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations.Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments.Molecular dissection of the events leading to inactivation of the FMR1 gene.Epstein-Barr virus transformation of human lymphoblastoid cells from patients with fragile X syndrome induces variable changes on CGG repeats size and promoter methylation.

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P2860

Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine.

http://www.wikidata.org/entity/Q39681923

description

2002 nî lūn-bûn

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Quantitative analysis of DNA d ...... eated with 5-azadeoxycytidine.

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Ben Oostra

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Elisabetta Tabolacci

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Giovanni Neri

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Maria Grazia Pomponi

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Pietro Chiurazzi

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Roberta Pietrobono

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P2860

The human 20-kDa 5'-(CGG)(n)-3'-binding protein is targeted to the nucleus and affects the activity of the FMR1 promoter

CpG methylation, chromatin structure and gene silencing-a three-way connection.

Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome

Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family.

Methylation mosaicism of 5'-(CGG)(n)-3' repeats in fragile X, premutation and normal individuals.

Hypomethylation of an expanded FMR1 allele is not associated with a global DNA methylation defect.

Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.

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