Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

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http://www.wikidata.org/entity/Q39703203

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

@zh-cn

2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

Discovery and SAR of novel ser ...... glutamate receptor 5 (mGlu5).

@en

Discovery and SAR of novel ser ...... abotropic glutamate receptor 5

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type

Item

label

Discovery and SAR of novel ser ...... glutamate receptor 5 (mGlu5).

@en

Discovery and SAR of novel ser ...... abotropic glutamate receptor 5

@nl

prefLabel

Discovery and SAR of novel ser ...... glutamate receptor 5 (mGlu5).

@en

Discovery and SAR of novel ser ...... abotropic glutamate receptor 5

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P1476

Discovery and SAR of novel ser ...... glutamate receptor 5 (mGlu5).

@en

P2093

Carlos M Martínez-Viturro

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Carrie K Jones

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Claire Mackie

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Gregor J Macdonald

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Han Min Tong

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Hilde Lavreysen

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J Scott Daniels

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José Manuel Bartolomé-Nebreda

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María Luz Martín-Martín

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Meredith J Noetzel

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P2860

Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex

Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory

Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

P304

1310-1317

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P31

scholarly article

P356

10.1016/J.BMCL.2015.01.038

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

P577

2015-01-28T00:00:00Z

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P698

25683622

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P932

4399811

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