Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. - Wikidata - awgldk - TriplyDB

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.

http://www.wikidata.org/entity/Q39723644

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Targeting the epigenome in lung cancer: expanding approaches to epigenetic therapy LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting CRISPR/Cas9 and cancer targets: future possibilities and present challenges Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations Functions of lncRNA HOTAIR in lung cancer The role of histone demethylases in cancer therapy Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Formaldehyde in brain: an overlooked player in neurodegeneration?Epigenome-based personalized medicine in human cancer KDM1 class flavin-dependent protein lysine demethylases LSD1 inhibition: a therapeutic strategy in cancer?The role of epigenetics in resistance to Cisplatin chemotherapy in lung cancer Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16 Cancer epigenetics: a brief review.Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1 Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.Chromatin proteins and modifications as drug targets.High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast Targeting histone lysine demethylases - progress, challenges, and the future Small-molecular modulators of cancer-associated epigenetic mechanisms.Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.A hypomorphic lsd1 allele results in heart development defects in mice Histone Demethylases in Colon Cancer.The functional role of long non-coding RNA in human carcinomas.Over-expression of lysine-specific demethylase 1 predicts tumor progression and poor prognosis in human esophageal cancer Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells.Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1 Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.

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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.

http://www.wikidata.org/entity/Q39723644

description

2011 nî lūn-bûn

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2011年论文

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2011年论文

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name

Overexpression of LSD1 contrib ...... regulation in various cancers.

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Overexpression of LSD1 contrib ...... regulation in various cancers.

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type

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Overexpression of LSD1 contrib ...... regulation in various cancers.

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Overexpression of LSD1 contrib ...... regulation in various cancers.

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prefLabel

Overexpression of LSD1 contrib ...... regulation in various cancers.

@en

Overexpression of LSD1 contrib ...... regulation in various cancers.

@nl

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International Journal of Cancer

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Overexpression of LSD1 contrib ...... regulation in various cancers.

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Bruce A J Ponder

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Helen I Field

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Hiroki Yamaue

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Hyun-Soo Cho

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John D Kelly

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Masanori Yoshimatsu

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Ryuji Hamamoto

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Shinya Hayami

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Tatsuhiko Tsunoda

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Yusuke Nakamura

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574-586

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scholarly article

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10.1002/IJC.25349

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3

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128

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