Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. - Wikidata - awgldk - TriplyDB

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

http://www.wikidata.org/entity/Q39752665

about

The human side of hypoxia-inducible factor Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling Hypoxic signaling during tissue repair and regenerative medicine HIF hydroxylase pathways in cardiovascular physiology and medicine DNA Damage and Pulmonary Hypertension Hypoxia-inducible factors in physiology and medicine Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet?Iron, oxygen, and the pulmonary circulation Archaic inheritance: supporting high-altitude life in Tibet Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology HIF prolyl hydroxylase inhibitors for anemia The impact of O2 availability on human cancer Regulation of respiration and endothelial gene expression by S-nitrosothiols in health and disease.Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.Emerging Metabolic Therapies in Pulmonary Arterial Hypertension.Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing Gene expression profiling of placentas affected by pre-eclampsia Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells.The physiological functions of iron regulatory proteins in iron homeostasis - an update.Prenatal programming of pulmonary hypertension induced by chronic hypoxia or ductal ligation in sheep The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1.High altitude pulmonary hypertension: role of K+ and Ca2+ channels.Human high-altitude adaptation: forward genetics meets the HIF pathway.Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease.Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans.The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5 Hypoxia-inducible factor as an angiogenic master switch The hypoxia-inflammation link and potential drug targets.Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.Hypoxia-induced pulmonary arterial smooth muscle cell proliferation is controlled by forkhead box M1.Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema.von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis Hypoxia-inducible factor as a physiological regulator.

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Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

http://www.wikidata.org/entity/Q39752665

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2003 nî lūn-bûn

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2003年学术文章

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Heterozygous deficiency of hyp ...... tion during prolonged hypoxia.

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Heterozygous deficiency of hyp ...... tion during prolonged hypoxia.

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Heterozygous deficiency of hyp ...... tion during prolonged hypoxia.

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Heterozygous deficiency of hyp ...... tion during prolonged hypoxia.

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Heterozygous deficiency of hyp ...... tion during prolonged hypoxia.

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Désiré Collen

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Koen Brusselmans

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Marc Tjwa

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Michael S Wiesener

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Patrick H Maxwell

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Veerle Compernolle

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P2860

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

Nitric oxide synthases: roles, tolls, and controls

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12750401

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arterial hypertension

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155039

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