Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.
about
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allMolecular programming of B cell memoryThe APOBEC3 family of retroelement restriction factorsTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityCrystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding DomainAnalysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityProximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells.Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.AID and somatic hypermutation.Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5Evidence for APOBEC3B mutagenesis in multiple human cancersSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progressionIdentification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity.Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cellsCell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.Does DNA repair occur during somatic hypermutation?DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsStructural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversificationNuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity.Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.APOBECs and virus restriction.AID Recognizes Structured DNA for Class Switch Recombination.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesD316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B.NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate.
P2860
Q26823568-0B85748B-0436-4CB1-944B-1DB6CB2E4684Q26829944-D65FDAC1-7781-401B-8227-123C65375F9FQ26862780-EEB550A3-FE0C-44E5-91BE-44AB3E523319Q26862917-259516A2-2884-44BE-BC4D-CA64C28C7826Q27678176-9F259100-7DA8-4047-A907-ECACAFAFBF3AQ30502490-5DDB9166-F390-4F6D-AC4D-9A842BBF9F88Q30537745-B0348C16-A30D-4A55-B89C-004E7F0C63C0Q33557562-B13DEA98-3C7B-4730-A883-2048295B7B31Q33764385-2009E205-0D7B-46B0-B07F-F53B40E6013EQ33819022-D5F93707-80B0-4A5E-B6D2-74526EB83304Q34115234-AEE12720-6C06-441F-A060-03C6F3F3B512Q34115490-1DD8FB2D-6E19-433D-BFEB-47EE3E9323AFQ34118000-BA5A77A9-128A-4E25-ADB0-715534C10B1AQ34137458-41A82297-E57E-4455-A2B9-097B6804CD70Q34357060-424347E1-4AB8-44FC-A639-28FE2F655F45Q34357412-28FD5CA5-6D04-42A1-AFEC-D923D66B7DB4Q34375128-160C5005-59C0-4088-B363-F9655F923396Q34412763-739FDD1D-4719-4EF6-9660-C2E5A19FF64BQ34536160-7DC7D10E-20C4-467C-BB33-64CD45BBAA82Q34982588-F223358A-B1BD-4D25-83FA-6B3C5BDDA4D1Q35105143-4F69CF01-459C-497C-A2CE-21A7A355C92FQ35305645-DBD818A5-A0E5-4D48-B3A0-223209346A7BQ35768862-CABE21ED-A7C3-493F-8808-1C70A73BDECAQ36173864-684313D9-5F53-4CBB-8E9C-E08771C43ED7Q36184715-9C731484-2DCB-4705-AF50-4849656DB1D7Q36261329-DADC81B3-BD2A-4730-B37A-6AF128F78F2CQ36301232-5E66B409-B72E-4BFF-B2EA-3C7B0C7962DEQ36305701-22089FCB-8F1B-4519-B19D-42626DB6B18CQ36842394-08AFC123-C929-4CC2-A0C4-EB54924D919BQ37029712-1A46506E-2C7A-473D-A06C-354088A54E4AQ37091342-9AE91FDA-13C7-4C35-83F2-346833606766Q37143544-2DD89DBC-D6DC-43ED-994E-8CB4345E7204Q37265843-4FE4B6EC-DC84-41B9-9780-32EF5968D382Q37402303-021AEB8C-BC9A-46DA-8F75-BC96F05FAE88Q37629738-330FF402-17E8-4154-BCAF-9CEEF1949382Q38394187-07F1A7AE-3A4E-4FD3-A149-FCA82950F92FQ38652890-ECF2D3E5-6B0A-451E-BB0A-C102D7074EF0Q38943944-0C0DE86F-E4F7-4B30-B1EA-80DF851B6096Q39173531-1236FD65-45F3-4A2F-941E-558CDA1A4F0CQ40261713-31A4705D-7A90-4A8A-AEEF-3885E297FB9A
P2860
Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Altering the spectrum of immun ...... ifying the active site of AID.
@en
Altering the spectrum of immun ...... ifying the active site of AID.
@nl
type
label
Altering the spectrum of immun ...... ifying the active site of AID.
@en
Altering the spectrum of immun ...... ifying the active site of AID.
@nl
prefLabel
Altering the spectrum of immun ...... ifying the active site of AID.
@en
Altering the spectrum of immun ...... ifying the active site of AID.
@nl
P2093
P2860
P356
P1476
Altering the spectrum of immun ...... ifying the active site of AID.
@en
P2093
Cristina Rada
Michael S Neuberger
P2860
P304
P356
10.1084/JEM.20092238
P407
P577
2010-01-04T00:00:00Z