MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. - Wikidata - awgldk - TriplyDB

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

http://www.wikidata.org/entity/Q39783024

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Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells Asparagine synthetase: a new potential biomarker in ovarian cancer.Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation Asparagine synthetase: regulation by cell stress and involvement in tumor biology Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G(1).Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway.Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation.Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs ATF4-dependent transcription mediates signaling of amino acid limitation.Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation.The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.Reversible HuR-microRNA binding controls extracellular export of miR-122 and augments stress response.Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements.The activities of the Yersinia protein kinase A (YpkA) and outer protein J (YopJ) virulence factors converge on an eIF2alpha kinase.Control of mammalian gene expression by amino acids, especially glutamine.An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation.GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.Cellular and animal indispensable amino acid limitation responses and health promotion. Can the two be linked? A critical review.GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy.Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines UVA, UVB and UVC induce differential response signaling pathways converged on the eIF2α phosphorylation.HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway.FGF21 mediates the lipid metabolism response to amino acid starvation.The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

P2860

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P2860

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

http://www.wikidata.org/entity/Q39783024

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2008 nî lūn-bûn

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2008年の論文

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name

MEK signaling is required for ...... of HepG2 human hepatoma cells.

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MEK signaling is required for ...... of HepG2 human hepatoma cells.

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MEK signaling is required for ...... of HepG2 human hepatoma cells.

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MEK signaling is required for ...... of HepG2 human hepatoma cells.

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P1433

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P1433

Journal of Biological Chemistry

P1476

MEK signaling is required for ...... of HepG2 human hepatoma cells

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P2093

Altin Gjymishka

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Can Zhong

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Michael S Kilberg

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Michelle M Thiaville

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Randal J Kaufman

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P2860

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Regulated translation initiation controls stress-induced gene expression in mammalian cells

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

The mammalian unfolded protein response

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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10848-10857

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10.1074/JBC.M708320200

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16

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phosphorylation

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2447663

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