Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila.
about
miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsCCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cellsStructural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding proteinThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsMammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationGW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationStructural features of Argonaute-GW182 protein interactionsMicroRNAs as controlled systems and controllers in non-alcoholic fatty liver diseaseThe panorama of miRNA-mediated mechanisms in mammalian cellsTranslational control mechanisms in metabolic regulation: critical role of RNA binding proteins, microRNAs, and cytoplasmic RNA granulesStructural insights into the human GW182-PABC interaction in microRNA-mediated deadenylationMei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signalingmicroRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Divergent GW182 functional domains in the regulation of translational silencing.All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay.The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.Mammalian GW220/TNGW1 is essential for the formation of GW/P bodies containing miRISC.The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells.Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.Allosteric regulation of Argonaute proteins by miRNAs.HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells.The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.GW182 controls Drosophila circadian behavior and PDF-receptor signaling.A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC.Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast.The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression.Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus.Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.
P2860
Q24292787-2652608B-BF8F-441D-9809-56C24F83B7A9Q24294694-98A507A0-1102-4BCB-99CA-0878342D5F58Q24300961-77056510-14B6-4266-8333-C8C5F4B82904Q24304318-DE36461F-E4F7-4006-BBFF-55CA66E0C601Q24310618-425401EF-3F73-402F-86D9-7E997FA2D5F6Q24323072-D95293A5-BE72-443C-A80A-E6FF7946B1EEQ24336642-9BB1F57A-ABCA-4252-BA17-0BB9C0487365Q26852606-7B88C9DD-8FE4-4F50-9476-39DDC7490A5AQ27001268-EFE24710-7EBA-4722-BF16-6C7EF63D71B2Q27022700-73312CCA-EC5E-42FE-84D7-EFCCF1871809Q27659139-235CD2E9-1A02-4AC1-BA02-3B0AA2621966Q28730787-B5115A7C-9BF6-4BF9-91E7-920410389778Q33497312-92251C08-1984-4631-A5A8-9D7634870C16Q33588085-A82AB070-310B-4AD2-9112-896A5301B163Q34278940-DA330DE8-7A5E-4D00-96D0-85E46D7E0D1BQ34779337-B433DC52-ADF7-4BA0-9FA4-15F41925DF3AQ35133366-8A10CF75-9DC7-42EE-B63E-96B3BC388B61Q36061917-E926D166-F818-4EF2-AAC5-926EE3672BADQ36418018-2EEF2B9F-66C9-4E4A-8039-A95142934939Q36444271-CDA04DA5-7328-482F-91FA-E898ABC42BC4Q37522850-BE3A5A6F-95A6-4B6F-9B2A-3A6B2BA98B2DQ38444337-A37B1387-AE0D-4D99-AB7F-0F12DD56E15FQ38747671-0C55F8F6-95D6-4E73-8267-C89D646D2354Q39437273-55C2D173-4973-405F-8E77-A6B49063608EQ39475198-80DF467E-74EE-4539-80D0-7F0AA5E406E0Q39726495-D7C732A4-C69B-44B1-80AF-44295E34467BQ39792632-AAF18697-FF7B-43F4-8C7C-7ABE49875295Q39869766-BACCAA41-E581-4118-ABF0-2F94E3FE65A5Q39926033-3E6DFC78-B217-4608-B0C8-779362639263Q40203675-7588DB9D-3E58-48D6-9B07-E67592957D2BQ42149351-2A06A345-402B-4615-9DD6-E6E30385054DQ42396003-7FEAAE52-52C5-4BAB-856D-C821FBA8F344Q42424730-BB4A07F0-910D-4A81-A81B-925C4B4B7F80Q42816046-C320AE9B-A5C8-472A-AD64-B0A8A488BD58Q47705794-955ABD2A-D9B9-4A6E-B08A-7158065418E2
P2860
Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Multiple independent domains o ...... ated repression in Drosophila.
@en
Multiple independent domains o ...... ated repression in Drosophila.
@nl
type
label
Multiple independent domains o ...... ated repression in Drosophila.
@en
Multiple independent domains o ...... ated repression in Drosophila.
@nl
prefLabel
Multiple independent domains o ...... ated repression in Drosophila.
@en
Multiple independent domains o ...... ated repression in Drosophila.
@nl
P2093
P2860
P356
P1433
P1476
Multiple independent domains o ...... ated repression in Drosophila.
@en
P2093
Marina Chekulaeva
Roy Parker
Witold Filipowicz
P2860
P304
P356
10.1261/RNA.1364909
P407
P577
2009-03-20T00:00:00Z