Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase.
about
A functional classification scheme for beta-lactamases and its correlation with molecular structureNovel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.Engineering a regulatable enzyme for homogeneous immunoassays.Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidimeEngineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.Active TEM-1 beta-lactamase mutants with random peptides inserted in three contiguous surface loops.RNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution.Mistranslation can enhance fitness through purging of deleterious mutations.Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.Characterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolateCombining computational and experimental screening for rapid optimization of protein propertiesIdentification of functional connections between calmodulin and the yeast actin cytoskeleton.Single amino acid replacements at positions altered in naturally occurring extended-spectrum TEM beta-lactamases.New system based on site-directed mutagenesis for highly accurate comparison of resistance levels conferred by SHV beta-lactamasesExtended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.Variability of chromosomally encoded beta-lactamases from Klebsiella oxytoca.Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strainStructure-based design of combinatorial mutagenesis librariesSystematic mutagenesis of the active site omega loop of TEM-1 beta-lactamaseDistinct roles of the repeat-containing regions and effector domains of the Vibrio vulnificus multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin.Selection of functional signal peptide cleavage sites from a library of random sequencesEnzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes.Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognitionCapnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.Selection of naturally occurring extended-spectrum TEM beta-lactamase variants by fluctuating beta-lactam pressure.The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon AcylationStructural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled β-lactamase.Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1.Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase.The Occurrence ofblaCTX-M,blaSHV, andblaTEMGenes in Extended-Spectrumβ-Lactamase-Positive Strains ofKlebsiella pneumoniae,Escherichia coli, andProteus mirabilisin Poland
P2860
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P2860
Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@en
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@nl
type
label
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@en
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@nl
prefLabel
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@en
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@nl
P2860
P1476
Identification of amino acid s ...... icity of TEM-1 beta-lactamase.
@en
P2093
Botstein D
Palzkill T
P2860
P304
P356
10.1128/JB.174.16.5237-5243.1992
P577
1992-08-01T00:00:00Z