Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells - Wikidata - awgldk - TriplyDB

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

http://www.wikidata.org/entity/Q30497680

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Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry The STIM1/Orai signaling machinery A critical survey of methods to detect plasma membrane rafts Store-operated Orai channels: structure and function An essential and NSF independent role for α-SNAP in store-operated calcium entry Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions.α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.PhotoGate microscopy to track single molecules in crowded environments.The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entry Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate Molecular biophysics of Orai store-operated Ca2+ channels.Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.STIM1L traps and gates Orai1 channels without remodeling the cortical ER Store-operated calcium channels: new perspectives on mechanism and function.Store-operated calcium entry: Mechanisms and modulation.Bringing single-molecule spectroscopy to macromolecular protein complexes.How many Orai's does it take to make a CRAC channel?The conserved tetrameric subunit stoichiometry of Slc26 proteins.Single molecule imaging approach to membrane protein stoichiometry.EGFP oligomers as natural fluorescence and hydrodynamic standards.Thiol dependent intramolecular locking of Orai1 channels.STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology Regulation of CRAC channels by protein interactions and post-translational modification.Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Exploring the unique features of the ARC channel, a store-independent Orai channel.Deciphering the subunit composition of multimeric proteins by counting photobleaching steps.Structural and functional mechanisms of CRAC channel regulation.Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells.Single-molecule methods to study membrane receptor oligomerization.Molecular mechanisms of STIM/Orai communication.Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.Determination of binding curves via protein micropatterning in vitro and in living cells.ER-plasma membrane junctions: Why and how do we study them?Gated regulation of CRAC channel ion selectivity by STIM1.Regulation of endogenous and heterologous Ca²⁺ release-activated Ca²⁺ currents by pH.Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.

P2860

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P2860

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

http://www.wikidata.org/entity/Q30497680

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Resting state Orai1 diffuses a ...... mbrane of live mammalian cells

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JBC.M110.177881

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Journal of Biological Chemistry

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Resting state Orai1 diffuses a ...... mbrane of live mammalian cells

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P2093

Barbara Lackner

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Gerhard J Schütz

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Marc Fahrner

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Reinhard Fritsch

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P2860

Orai1 is an essential pore subunit of the CRAC channel

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

Store-operated calcium channels

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane.

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.

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41135-41142

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scholarly article

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10.1074/JBC.M110.177881

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52

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285

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Christoph Romanin

Julian Weghuber

Irene Frischauf

Isabella Derler

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2010-10-20T00:00:00Z

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20961852

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3003411

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