Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. - Wikidata - awgldk - TriplyDB

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

http://www.wikidata.org/entity/Q40051013

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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus Phosphoinositides: Key modulators of energy metabolism Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation Modeling integrated cellular machinery using hybrid Petri-Boolean networks Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.ENPP1 affects insulin action and secretion: evidences from in vitro studies.Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion.JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice Erythropoietin protects against diabetes through direct effects on pancreatic beta cells Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.AKT1 polymorphisms are associated with risk for metabolic syndrome.Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis Norepinephrine stimulates mobilization of endothelial progenitor cells after limb ischemia.Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice Akt and PTEN: beta-cell mass and pancreas plasticity.Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells Various oscillation patterns of serum fibroblast growth factor 21 concentrations in healthy volunteers.APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice Fractalkine signaling in regulation of insulin secretion.Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.

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P2860

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

http://www.wikidata.org/entity/Q40051013

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Defective insulin secretion an ...... n pancreatic islet beta cells.

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Defective insulin secretion an ...... n pancreatic islet beta cells.

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P2093

Ernesto Bernal-Mizrachi

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James D Johnson

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Kenichi Otani

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Kenneth S Polonsky

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M Alan Permutt

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Mitsuru Ohsugi

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Szabolcs Fatrai

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Zhiqiang Han

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P2860

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

Disruption of IRS-2 causes type 2 diabetes in mice

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets

Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells.

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Increased islet apoptosis in Pdx1+/- mice

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

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928-936

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10.1172/JCI200420016

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15467831

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518659

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