Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.
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Mthfs is an Essential Gene in Mice and a Component of the PurinosomeBioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genesIdentification of a de novo thymidylate biosynthesis pathway in mammalian mitochondriaSHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesisUbc13: the Lys63 ubiquitin chain building machineAmino acid management in cancerSumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesisModeling cellular compartmentation in one-carbon metabolismALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenaseMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosAn active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondriaMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesA genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysisPhylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymesHuman polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation.Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisAzoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.Regulation and functional contribution of thymidine kinase 1 in repair of DNA damageNuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiencyPolymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.Histone demethylase LSD1 is a folate-binding proteinMaternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNACompetition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus.The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects.Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white malesCytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in miceMthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Mouse models to elucidate mechanisms of folate-related cancer pathologies.One-carbon metabolism-genome interactions in folate-associated pathologies.A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair.Trafficking of intracellular folates.Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage.Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.
P2860
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P2860
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Evidence for small ubiquitin-l ...... midylate biosynthesis pathway.
@en
type
label
Evidence for small ubiquitin-l ...... midylate biosynthesis pathway.
@en
prefLabel
Evidence for small ubiquitin-l ...... midylate biosynthesis pathway.
@en
P2093
P2860
P356
P1476
Evidence for small ubiquitin-l ...... midylate biosynthesis pathway.
@en
P2093
Collynn F Woeller
Doletha M E Szebenyi
Donald D Anderson
Patrick J Stover
P2860
P304
17623-17631
P356
10.1074/JBC.M702526200
P407
P577
2007-04-19T00:00:00Z