Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice - Wikidata - awgldk - TriplyDB

Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice

Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice

http://www.wikidata.org/entity/Q36871683

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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis Modeling cellular compartmentation in one-carbon metabolism How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis Folic acid in early pregnancy: a public health success story A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.Formate metabolism in fetal and neonatal sheep Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus.Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice.Dietary folic acid protects against genotoxicity in the red blood cells of mice.One-carbon metabolism-genome interactions in folate-associated pathologies.A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair.Genetic and epigenomic footprints of folate.Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.Trafficking of intracellular folates.Glycine metabolism in animals and humans: implications for nutrition and health.

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P2860

Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice

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2008 nî lūn-bûn

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2008年论文

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Cytoplasmic serine hydroxymeth ...... e but is not essential in mice

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Cytoplasmic serine hydroxymeth ...... e but is not essential in mice

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Cytoplasmic serine hydroxymeth ...... e but is not essential in mice

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Amanda J MacFarlane

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Cheryll A Perry

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Patrick J Stover

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Per Flodby

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Robert H Allen

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Sally P Stabler

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Xiaowen Liu

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P2860

Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers

Pathways and regulation of homocysteine metabolism in mammals.

Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.

Physiology of folate and vitamin B12 in health and disease.

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals.

Compartmentation of folate-mediated one-carbon metabolism in eukaryotes.

Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.

Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation.

Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.

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25846-25853

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10.1074/JBC.M802671200

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38

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283

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18644786

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2533799

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