Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
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c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stabilitySolution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignIdentification and characterization of putative methylation targets in the MAOA locus using bioinformatic approachesMolecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNAI-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stabilityStructural insights into G-quadruplexes: towards new anticancer drugs.The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intramGaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.Polycyclic azoniahetarenes: assessing the binding parameters of complexes between unsubstituted ligands and G-quadruplex DNA.Targeting MYC Expression through G-Quadruplexes.A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.Small molecules targeting c-Myc oncogene: promising anti-cancer therapeuticsIdentification of a selective G-quadruplex DNA binder using a multistep virtual screening approach.The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structuresDemonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule.Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoterDiscovery of a Family of Genomic Sequences Which Interact Specifically with the c-MYC Promoter to Regulate c-MYC Expression.Sequence, stability, and structure of G-quadruplexes and their interactions with drugsStrategies to Inhibit Myc and Their Clinical ApplicabilityOld drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1αTargeting MYC in cancer therapy: RNA processing offers new opportunities.DNA G-quadruplex and its potential as anticancer drug targetStructures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.Self-assembly of c-myc DNA promoted by a single enantiomer ruthenium complex as a potential nuclear targeting gene carrierA hitchhiker's guide to G-quadruplex ligands.The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo.The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences.G-quadruplex structures in the human genome as novel therapeutic targets.G-quadruplexes as potential therapeutic targets for embryonal tumors.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Discovery of a natural product-like c-myc G-quadruplex DNA groove-binder by molecular docking.
P2860
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P2860
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Stabilization of G-quadruplex ...... myc by quindoline derivatives.
@en
type
label
Stabilization of G-quadruplex ...... myc by quindoline derivatives.
@en
prefLabel
Stabilization of G-quadruplex ...... myc by quindoline derivatives.
@en
P2093
P356
P1476
Stabilization of G-quadruplex ...... myc by quindoline derivatives.
@en
P2093
Albert Sun-Chi Chan
Jia-Heng Tan
Johnny Cheuk-On Tang
Lian-Quan Gu
Tian-Miao Ou
Xiao-Dong Wang
Yu-Jing Lu
Zhi-Shu Huang
P304
P356
10.1021/JM0610088
P407
P577
2007-03-09T00:00:00Z