Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.
about
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionTFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's diseaseParkin Regulation and Neurodegenerative DisordersRBR E3 ubiquitin ligases: new structures, new insights, new questionsPINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress.Cancer and neurodegeneration: between the devil and the deep blue sea.Synaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyParkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.Oxidative stress in neurodegenerationPhosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death.Deregulated Cdk5 activity is involved in inducing Alzheimer's diseaseParkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.The parkin protein as a therapeutic target in Parkinson's disease.Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationAF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons.Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway?Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Molecular pathology of Lewy body diseases.Genetic insights into sporadic Parkinson's disease pathogenesis.Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.Cdk5: mediator of neuronal development, death and the response to DNA damage.Regulation of Parkin E3 ubiquitin ligase activity.Programmed cell death in Parkinson's diseaseAn emerging role of PARK2 in cancer.Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.The c-Abl inhibitor in Parkinson disease.Post translational modification of Parkin.Phosphorylation of mouse serine racemase regulates D-serine synthesis.Combined kinase inhibition modulates parkin inactivation.Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
P2860
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P2860
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Phosphorylation of Parkin by t ...... gase activity and aggregation.
@en
type
label
Phosphorylation of Parkin by t ...... gase activity and aggregation.
@en
prefLabel
Phosphorylation of Parkin by t ...... gase activity and aggregation.
@en
P2093
P2860
P356
P1476
Phosphorylation of Parkin by t ...... igase activity and aggregation
@en
P2093
Esti Liani
Eyal Avraham
Raymonde Szargel
P2860
P304
12842-12850
P356
10.1074/JBC.M608243200
P407
P577
2007-02-27T00:00:00Z