Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.
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Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein.Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequencesIn vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studiesUbiquitination and deubiquitination of REST and its roles in cancersThe quest for restoring hearing: Understanding ear development more completely.Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 GenesCerebellum development and medulloblastomaNuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellumConditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cellsRobust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification.HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma.Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neuronsIn vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development.Identification of small molecule activators of BMP signalingA new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular contextIn vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cordIntracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice.Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells.Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.Medulloblastoma or not? Crucial role in tumorigenesis of the timing of migration of cerebellar granule precursor cells, regulated by Nos2 and Tis21MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.Cerebellum Development and Tumorigenesis: A p53-Centric Perspective.Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.Limited effects of preterm birth and the first enteral nutrition on cerebellum morphology and gene expression in piglets.Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1.Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine.Engrailed2 modulates cerebellar granule neuron precursor proliferation, differentiation and insulin-like growth factor 1 signaling during postnatal developmentThe perivascular niche microenvironment in brain tumor progression.Can clues from evolution unlock the molecular development of the cerebellum?Medulloblastoma stem cells: where development and cancer cross pathways.What underlies the diversity of brain tumors?A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma.The role of Atonal transcription factors in the development of mechanosensitive cells.Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro.
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P2860
Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Deletion of Atoh1 disrupts Son ...... and prevents medulloblastoma.
@en
type
label
Deletion of Atoh1 disrupts Son ...... and prevents medulloblastoma.
@en
prefLabel
Deletion of Atoh1 disrupts Son ...... and prevents medulloblastoma.
@en
P2093
P2860
P356
P1433
P1476
Deletion of Atoh1 disrupts Son ...... and prevents medulloblastoma.
@en
P2093
Adriano Flora
Gabriele Schuster
Tiemo J Klisch
P2860
P304
P356
10.1126/SCIENCE.1181453
P407
P50
P577
2009-12-01T00:00:00Z