A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).
about
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannerPromoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayPhosphoinositides: Key modulators of energy metabolismPark7 expression influences myotube size and myosin expression in musclePTEN regulates cilia through Dishevelled.Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancerTreponema denticola major outer sheath protein induces actin assembly at free barbed ends by a PIP2-dependent uncapping mechanism in fibroblastsTreponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxisAccelerated wound healing by mTOR activation in genetically defined mouse models.A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisIdentification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes.Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor.Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypesA new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis.Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis.PTEN inhibitors cause a negative inotropic and chronotropic effect in mice.Removal or masking of phosphatidylinositol(4,5)bisphosphate from the outer mitochondrial membrane causes mitochondrial fragmentation.Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN.Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse modelTAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BONThe PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.Role of PTEN in TNFα induced insulin resistanceA novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest.Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src ActivationArylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells.Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cellsA recessive form of extreme macrocephaly and mild intellectual disability complements the spectrum of PTEN hamartoma tumour syndromePhosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes.Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog ExpressionProtein tyrosine phosphatases: dual-specificity phosphatases in health and disease.TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice.Inhibition of the phosphatase PTEN protects mice against oleic acid-induced acute lung injuryA PTEN inhibitor displays preclinical activity against hepatocarcinoma cellsA novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell.mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia.Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway.PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
P2860
Q24337323-C48AC474-CCD5-4BE5-B327-852F9C278308Q24644113-C68F527B-36C1-465B-BFB0-ED3CA2587257Q27022953-029C6A43-7957-4012-8EFE-A3052CACC3FDQ27314984-F51BD928-0A1A-4EFF-8878-D5E426740274Q28267704-FE2CFCF4-59B7-49AF-AD12-D71D12F64FB5Q28475229-98F72AFA-5D3F-41AD-902F-8E497D259322Q28476710-6FFF98D2-73C1-4556-9A33-7574DD8C5B1CQ28533593-AECB6B3D-02AD-4523-A8CF-929F19F14C8CQ30389607-06648E6F-9CC8-4A13-A9FD-46D0FCCC89E2Q33685619-2B31C450-2803-4BFE-99B6-5631631B055FQ33726915-E979CB79-2E3E-408D-B654-A331F3D867BCQ33874508-5A7BEC95-5E7A-4A9B-AE82-CEC86B967D6DQ34096820-87583961-E22D-4B64-813C-813A60818FF8Q34236641-CD242FF2-25F4-4572-BB03-FAFF3F48923CQ34316072-57D37C33-606D-402A-BC07-69E640222A97Q34384591-66F5801C-112F-496B-926F-C0DE0E694687Q34548085-1D869CBF-DF4F-4A03-A4F0-076143635C9EQ35023863-42A0A412-9704-46F4-A0F2-842198CD831FQ35067637-018B9C21-8C37-4DBD-A100-8967E5F5E545Q35154138-ED35FDC6-0672-4534-A6D2-D7D62ECC1DD2Q35178600-AB301DFB-FA82-48D3-BE70-EC5BE03D2CA9Q35347580-C5026A45-44F7-46FE-BB5A-3F523C7B8FA4Q35613134-4F0B824F-36E3-408D-BA32-4EF2881582B2Q35671732-AF3A5EE1-BA9A-4387-AE7D-C822A3A0C135Q36034029-DC9EF3D4-CCA1-42E0-82FE-B100D7F4F813Q36074853-16F781F4-78B1-4D63-ADED-DE610239B47BQ36140051-926C9AE8-09D3-438A-8D91-F28B3AD92C35Q36217557-576C3522-AEF4-4D0C-8A91-5B08DD1AF4B9Q36536616-637D89A9-0A34-49CB-966F-AC1AA594E3B2Q36763145-187C18DA-7A63-411D-96B2-F4E041366F96Q37029553-5EDDAD6F-B4E9-450C-9C05-98AA6E358648Q37052016-D879463C-071F-4321-B7B9-28949157B7ADQ37094068-93189D6C-10D7-4474-BD81-7C7B35856BE2Q37209584-409BC7D7-FA3E-4343-8135-29F715995369Q37230865-EF1AE6E9-1314-4C47-BCB3-831F2D00F280Q37324522-1E830F9A-5DC7-4E56-B8DD-EF4BDAF94FA1Q37392640-ED83362B-0807-43CE-9542-AE502C8119E7Q37439191-5807BAD5-F4AB-44BD-8110-ED66C0678111Q37479693-BF5677DF-04AE-4D71-8263-1D5DCA31DD79Q37527357-1302CECF-EB3E-4368-90D6-0B992E21973E
P2860
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A small molecule inhibitor for ...... leted on chromosome 10 (PTEN).
@en
type
label
A small molecule inhibitor for ...... leted on chromosome 10 (PTEN).
@en
prefLabel
A small molecule inhibitor for ...... leted on chromosome 10 (PTEN).
@en
P2093
P356
P1433
P1476
A small molecule inhibitor for ...... leted on chromosome 10 (PTEN).
@en
P2093
Annette C Schmid
Christophe Erneux
Erika Rosivatz
Jonathan G Matthews
Karen M Pomeranz
Marianna Mirabelli
Nadine Lossi
Neil Q McDonald
Rüdiger Woscholski
P304
P356
10.1021/CB600352F
P577
2006-12-01T00:00:00Z