Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
about
Signalling in the epidermis: the E2F cell cycle regulatory pathway in epidermal morphogenesis, regeneration and transformationCDK4is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancerIntegrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone.Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma.Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship.Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesisUnexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.Elevated expression of CDK4 in lung cancer.Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epitheliumCombined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor developmentDrosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress.Systems biology and the molecular circuits of cancer.CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth controlModelling cancer in human skin tissue.Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer.CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulationp21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesisDisrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation.Cell cycle proteins as promising targets in cancer therapySkin Tumors Rb(eing) Uncovered.Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.CDK4 in lung, and head and neck cancers in old age: evaluation as a biomarker.Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma.Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation.PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin.Characterization of hair-follicle side population cells in mouse epidermis and skin tumors.Nuclear expression of CDK4 correlates with disease progression and poor prognosis in human nasopharyngeal carcinoma.The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis.Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis.
P2860
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P2860
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
@en
type
label
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
@en
prefLabel
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
@en
P2093
P2860
P356
P1433
P1476
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
@en
P2093
Claudio J Conti
Everardo Macias
Marcelo L Rodriguez-Puebla
Paula L Miliani de Marval
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207309
P407
P577
2004-03-01T00:00:00Z
P5875
P6179
1020097658