Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
about
Identification of RPS14 as a 5q- syndrome gene by RNA interference screenα-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1Myeloid malignancies: mutations, models and managementKnockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in miceDLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctionsNew functions for alpha-catenins in health and disease: from cancer to heart regenerationTcf3 and Tcf4 are essential for long-term homeostasis of skin epitheliaThe role of lenalidomide in the management of myelodysplasia with del 5q.Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.Heritable and lineage-specific gene knockdown in zebrafish embryoPrediction of potential cancer-risk regions based on transcriptome data: towards a comprehensive viewEpigenetic changes in the myelodysplastic syndrome.Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.α-catenin. A tumor suppressor beyond adherens junctions.Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results.Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Ribosomopathies: mechanisms of disease.Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.Genome-wide epigenetic modifications in cancer.Genetic pathways leading to therapy-related myeloid neoplasms.Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathwayChromosome 5q deletion is extremely rare in patients with myelofibrosisAllelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AMLLoss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signalingTargeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy.Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletionsCytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.Genetics of therapy-related myelodysplasia and acute myeloid leukemia.Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.
P2860
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P2860
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Chromosome 5q deletion and epi ...... n myeloid cell transformation.
@en
type
label
Chromosome 5q deletion and epi ...... n myeloid cell transformation.
@en
prefLabel
Chromosome 5q deletion and epi ...... n myeloid cell transformation.
@en
P2093
P2860
P356
P1433
P1476
Chromosome 5q deletion and epi ...... n myeloid cell transformation.
@en
P2093
A Thomas Look
Daniel J DeAngelo
Ilene A Galinsky
Jaroslav Jelinek
Jean-Pierre Issa
Michael F Clarke
Michael W Becker
Natallia Mikhalkevich
P2860
P2888
P356
10.1038/NM1512
P407
P577
2006-12-10T00:00:00Z
P5875
P6179
1005627875