Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. - Wikidata - awgldk - TriplyDB

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

http://www.wikidata.org/entity/Q40198158

about

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1 Myeloid malignancies: mutations, models and management Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctions New functions for alpha-catenins in health and disease: from cancer to heart regeneration Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia The role of lenalidomide in the management of myelodysplasia with del 5q.Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.Heritable and lineage-specific gene knockdown in zebrafish embryo Prediction of potential cancer-risk regions based on transcriptome data: towards a comprehensive view Epigenetic changes in the myelodysplastic syndrome.Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.α-catenin. A tumor suppressor beyond adherens junctions.Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results.Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Ribosomopathies: mechanisms of disease.Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.Genome-wide epigenetic modifications in cancer.Genetic pathways leading to therapy-related myeloid neoplasms.Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway Chromosome 5q deletion is extremely rare in patients with myelofibrosis Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy.Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425 Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.Genetics of therapy-related myelodysplasia and acute myeloid leukemia.Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.

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Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

http://www.wikidata.org/entity/Q40198158

description

2006 nî lūn-bûn

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2006年论文

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name

Chromosome 5q deletion and epi ...... n myeloid cell transformation.

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Chromosome 5q deletion and epi ...... n myeloid cell transformation.

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Chromosome 5q deletion and epi ...... n myeloid cell transformation.

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Nature Medicine

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Chromosome 5q deletion and epi ...... n myeloid cell transformation.

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A Thomas Look

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Daniel J DeAngelo

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Ilene A Galinsky

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Jaroslav Jelinek

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Jean-Pierre Issa

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Karl Hsu

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Michael F Clarke

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Michael W Becker

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Min Deng

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Natallia Mikhalkevich

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P2860

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases

High sensitivity mapping of methylated cytosines

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)

Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin

Identification of the haematopoietic stem cell niche and control of the niche size

Asymmetric cell divisions promote stratification and differentiation of mammalian skin.

Physical mapping of the minimal region of loss in 5q- chromosome.

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78-83

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10.1038/NM1512

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1

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13

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Clara D. Bloomfield

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2006-12-10T00:00:00Z

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6639670

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1005627875

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17159988

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