Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.
about
Targeting the B-cell receptor signaling pathway in B lymphoid malignanciesExpression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in miceSYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia.SYK regulates mTOR signaling in AML.STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.BCL6 is critical for the development of a diverse primary B cell repertoire.Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target.SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphomaRAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.The SYK tyrosine kinase: a crucial player in diverse biological functions.Aberrant cytokine signaling in leukemia.B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytesTherapeutic prospect of Syk inhibitors.Is there a role for differentiating therapy in non-APL AML?The Syk kinase as a therapeutic target in leukemia and lymphoma.Extramedullary hematopoiesis (EMH) in laboratory animals: offering an insight into stem cell research.The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.Pre-B cell receptor signaling in acute lymphoblastic leukemia.Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase.Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways.Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells.The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation.Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy.Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.Activation of Syk in peripheral blood B cells in patients with rheumatoid arthritis: a potential target for abatacept therapy.
P2860
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P2860
Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Deregulated Syk inhibits diffe ...... proliferation of pre-B cells.
@en
type
label
Deregulated Syk inhibits diffe ...... proliferation of pre-B cells.
@en
prefLabel
Deregulated Syk inhibits diffe ...... proliferation of pre-B cells.
@en
P2093
P2860
P356
P1476
Deregulated Syk inhibits diffe ...... t proliferation of pre-B cells
@en
P2093
Akihiro Abe
Arndt Borkhardt
Fabian Köhler
Gerhard Mittler
Hassan Jumaa
Sonja Meixlsperger
Thomas Wossning
P2860
P304
P356
10.1084/JEM.20060967
P407
P577
2006-11-27T00:00:00Z