Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. - Wikidata - awgldk - TriplyDB

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks.

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks.

http://www.wikidata.org/entity/Q40212438

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Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells DNA Damage Response in Hematopoietic Stem Cell Ageing Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks A systematic proteomic study of irradiated DNA repair deficient Nbn-mice ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks Rad50 is dispensable for the maintenance and viability of postmitotic tissues BRCA2 is required for neurogenesis and suppression of medulloblastoma Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognition Limiting the persistence of a chromosome break diminishes its mutagenic potential.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50 Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1 Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability Mouse models of DNA double-strand break repair and neurological disease Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.Human RIF1 encodes an anti-apoptotic factor required for DNA repair Choreography of recombination proteins during the DNA damage response.The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.Regulation of Single-Strand Annealing and its Role in Genome Maintenance.E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.Systematic characterization of cell cycle phase-dependent protein dynamics and pathway activities by high-content microscopy-assisted cell cycle phenotyping.The effects of 41 degrees C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines.The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.DNA damage and oxidative injury are associated with hypomyelination in the corpus callosum of newborn Nbn(CNS-del) mice.Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes.

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Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks.

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The EMBO Journal

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Conditional deletion of Nbs1 i ...... s of DNA double-strand breaks.

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Amal Saidi

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Christelle Barrucand

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Jocelyne Michelon

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Valérie Dumon-Jones

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Wookee Min

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Yun-Gui Yang

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Zdenko Herceg

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Zhao-Qi Wang

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P2860

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

DNA double-strand breaks: signaling, repair and the cancer connection

Molecular views of recombination proteins and their control

Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

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Pierre-Olivier Frappart

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2006-11-02T00:00:00Z

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