The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
about
COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseCSN controls NF-kappaB by deubiquitinylation of IkappaBalphaThe COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian functionTargeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agentFunction of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradationCharacterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagyRegulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcinPhosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.A protein network-guided screen for cell cycle regulators in Drosophila.Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.Cullin E3 ligases and their rewiring by viral factorsThe COP9 signalosome and cullin-RING ligases in the heartThe COP9 signalosome and vascular function: intriguing possibilities?CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsCLCuMuB βC1 Subverts Ubiquitination by Interacting with NbSKP1s to Enhance Geminivirus Infection in Nicotiana benthamiana.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.The organization of a CSN5-containing subcomplex of the COP9 signalosome.Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.Targeting p27Kip1 protein: its relevance in the therapy of human cancer.Roles of COP9 signalosome in cancer.COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.Geminivirus C2 protein might be the key player for geminiviral co- option of SCF-mediated ubiquitinationCOP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.F-box-directed CRL complex assembly and regulation by the CSN and CAND1Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells.Geminiviruses subvert ubiquitination by altering CSN-mediated derubylation of SCF E3 ligase complexes and inhibit jasmonate signaling in Arabidopsis thaliana.COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexesCOP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complexGene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain.
P2860
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P2860
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
@en
type
label
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
@en
prefLabel
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.
@en
P2860
P356
P1476
The COP9 signalosome regulates Skp2 levels and proliferation of human cells
@en
P2093
Elisabetta Bianchi
Simona Denti
P2860
P304
32188-32196
P356
10.1074/JBC.M604746200
P407
P577
2006-08-30T00:00:00Z