The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers.
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Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 functionThe tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisMelanosomes--dark organelles enlighten endosomal membrane transportPMEL Amyloid Fibril Formation: The Bright Steps of PigmentationPhysiological factors that regulate skin pigmentationMutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.Multiple splice variants within the bovine silver homologue (SILV) gene affecting coat color in cattle indicate a function additional to fibril formation in melanophores.Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions.The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Rab7 is a critical mediator in vesicular transport of tyrosinase-related protein 1 in melanocytes.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenicMolecular origin of pH-dependent fibril formation of a functional amyloidEffects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH.Lysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17.Proprotein convertases process Pmel17 during secretion.Structural insights into functional and pathological amyloid.Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules.Segmental polymorphism in a functional amyloid.Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue levelMechanisms of protein delivery to melanosomes in pigment cells.Comprehensive characterization of mesenchymal stem cells from human placenta and fetal membrane and their response to osteoactivin stimulation.Heterogeneity of Metastatic Melanoma: Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1.Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitf(mi) and Mitf(vitiligo) mouse mutants.Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils.Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.PMEL: a pigment cell-specific model for functional amyloid formationThe PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.A novel approach to enhance antibody sensitivity and specificity by peptide cross-linking.Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretaseThe yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesisA mutation within the transmembrane domain of melanosomal protein Silver (Pmel17) changes lumenal fragment interactions.FIG4, Charcot-Marie-Tooth disease, and hypopigmentation: a role for phosphoinositides in melanosome biogenesis?N-terminal domains elicit formation of functional Pmel17 amyloid fibrilsMelanosomal formation of PMEL core amyloid is driven by aromatic residues.
P2860
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P2860
The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The repeat domain of the melan ...... ormation of organellar fibers.
@en
type
label
The repeat domain of the melan ...... ormation of organellar fibers.
@en
prefLabel
The repeat domain of the melan ...... ormation of organellar fibers.
@en
P2093
P356
P1476
The repeat domain of the melan ...... ormation of organellar fibers.
@en
P2093
Francois Rouzaud
Jacqueline Muller
Kanako Kikuchi
Kunihiko Tamaki
Toshihiko Hoashi
Vincent J Hearing
Wilfred D Vieira
P304
21198-21208
P356
10.1074/JBC.M601643200
P407
P577
2006-05-08T00:00:00Z