Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
about
Sodium channel molecular conformations and antiarrhythmic drug affinityThe hitchhiker's guide to the voltage-gated sodium channel galaxyCommon molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsBlockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugsNeuromyotonia in hereditary motor neuropathy.Use-dependent inhibition of Na+ currents by benzocaine homologs.Distinct local anesthetic affinities in Na+ channel subtypesCharged tetracaine as an inactivation enhancer in batrachotoxin-modified Na+ channels.Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access.Modification of cardiac Na+ channels by batrachotoxin: effects on gating, kinetics, and local anesthetic binding.Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism.Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore.QX-314 restores gating charge immobilization abolished by chloramine-T treatment in squid giant axons.Characterization of cocaine-induced block of cardiac sodium channels.Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacainepH-dependent binding of local anesthetics in single batrachotoxin-activated Na+ channels. Cocaine vs. quaternary compounds.Single inward rectifier potassium channels in guinea pig ventricular myocytes. Effects of quinidineMolecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsBlock and inactivation of sodium channels in nerve by amino acid derivatives. II. Dependence on temperature and drug concentrationThe effect of tetramethylammonium on single sodium channel currents.Saxitoxin and tetrodotoxin. Electrostatic effects on sodium channel gating current in crayfish axons.Effects of benzocaine on the kinetics of normal and batrachotoxin-modified Na channels in frog node of Ranvier.Batrachotoxin uncouples gating charge immobilization from fast Na inactivation in squid giant axons.Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.Kinetic analysis of sodium channel block by internal methylene blue in pronased crayfish giant axons.Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.BOLD fMRI of C-Fiber Mediated Nociceptive Processing in Mouse Brain in Response to Thermal Stimulation of the Forepaws.Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel.Alamethicin channels incorporated into frog node of ranvier: calcium-induced inactivation and membrane surface charges.Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gatingInteractions of organic calcium channel antagonists with calcium channels in single frog atrial cellsBinding of benzocaine in batrachotoxin-modified Na+ channels. State-dependent interactions.Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.Molecular action of lidocaine on the voltage sensors of sodium channelsAn inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+.Interaction between the pore and a fast gate of the cardiac sodium channel.Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.Site-3 toxins and cardiac sodium channels.Antagonism of lidocaine inhibition by open-channel blockers that generate resurgent Na current.
P2860
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P2860
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
@en
type
label
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
@en
prefLabel
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
@en
P2860
P1433
P1476
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
@en
P2093
P2860
P356
10.1016/S0006-3495(79)85201-7
P407
P577
1979-07-01T00:00:00Z