Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
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The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityGetting 'Smad' about obesity and diabetesIslet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.Glucose-stimulated insulin response in pregnant sheep following acute suppression of plasma non-esterified fatty acid concentrationsObesity and insulin resistance: an abridged molecular correlationChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsOverexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretionPalmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic isletsDeletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cellsIdentification of differential responses to an oral glucose tolerance test in healthy adultsStress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic isletsNeprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx.Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.Macrophages transfer [14C]-labelled fatty acids to pancreatic islets in culture.Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.An islet in distress: β cell failure in type 2 diabetes.Role and mechanism of pancreatic β-cell death in diabetes: The emerging role of autophagy.Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolismGlucolipotoxicity of the pancreatic beta cell.Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes.Lipotoxicity and decreased islet graft survivalEvolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes MellitusADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes.Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.Milk and diabetes.Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats.Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerolBiochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Free fatty acids--do they play a central role in type 2 diabetes?Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosisFree fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors.Serotonin receptor 2C and insulin secretionMaternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspringFree fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways.Adipocyte triglyceride lipase expression in human obesity.
P2860
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P2860
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Long-term exposure of rat panc ...... gh a glucose fatty acid cycle.
@en
type
label
Long-term exposure of rat panc ...... gh a glucose fatty acid cycle.
@en
prefLabel
Long-term exposure of rat panc ...... gh a glucose fatty acid cycle.
@en
P2860
P921
P356
P1476
Long-term exposure of rat panc ...... gh a glucose fatty acid cycle.
@en
P2093
P2860
P304
P356
10.1172/JCI117042
P407
P577
1994-02-01T00:00:00Z