Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. - Wikidata - awgldk - TriplyDB

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

http://www.wikidata.org/entity/Q40344643

about

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors Phenotypic Characterization of Resistant Val36 Variants of Hepatitis C Virus NS3-4A Serine Protease In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors Structure-function relationships among RNA-dependent RNA polymerases A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796 Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors 2-Meth-oxy-6-(6-methyl-1H-benzimid-azol-2-yl)phenol.3-[1-(3-Hydroxy-benz-yl)-1H-benz-imid-azol-2-yl]phenol.2-Methyl-6-(6-methyl-1H-benzimidazol-2-yl)phenol-2-methyl-6-(5-methyl-1H-benzimidazol-2-yl)phenol (3/1).Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase.Therapeutic implications of hepatitis C virus resistance to antiviral drugs.Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.

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P2860

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

http://www.wikidata.org/entity/Q40344643

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2003 nî lūn-bûn

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Mechanism of action and antivi ...... RNA-dependent RNA polymerase.

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Mechanism of action and antivi ...... RNA-dependent RNA polymerase.

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Mechanism of action and antivi ...... RNA-dependent RNA polymerase.

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JVI.77.24.13225-13231.2003

P1433

Journal of Virology

P1476

Mechanism of action and antivi ...... s RNA-dependent RNA polymerase

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P2093

Alessandra Ceccacci

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Antonino Biroccio

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Frank Narjes

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Giovanni Migliaccio

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Ian Stansfield

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Ilario Incitti

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Laura Orsatti

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Licia Tomei

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Linda Bartholomew

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Michael Rowley

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P2860

Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.

A mechanism for initiating RNA-dependent RNA polymerization

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13225-13231

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scholarly article

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10.1128/JVI.77.24.13225-13231.2003

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24

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77

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Raffaele De Francesco

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2003-12-01T00:00:00Z

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8984391

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14645579

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allosteric inhibitor

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296079

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