GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
about
Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cellsMicrotubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarityGSK-3: Functional Insights from Cell Biology and Animal Models.High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.What Are the bona fide GSK3 Substrates?Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.Derepression of pathological cardiac genes by members of the CaM kinase superfamily.GSK3 signalling in neural development.Implication of Wnt signaling in neuronal polarization.Protein phosphorylation in neurodegeneration: friend or foe?Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity.The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons.MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.
P2860
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P2860
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
@en
type
label
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
@en
prefLabel
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
@en
P2093
P2860
P356
P1476
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
@en
P2093
Etsu Tashiro
Masaya Imoto
Mayumi Ueki
Shinichi Kosuga
Toshifumi Kajioka
Yoshifumi Shimizu
P2860
P304
42715-42722
P356
10.1074/JBC.M507941200
P407
P577
2005-10-28T00:00:00Z