Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing.
about
The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinNuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicingHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.Prp8 protein: at the heart of the spliceosomeIdentification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle controlThe C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice siteThe human Prp8 protein is a component of both U2- and U12-dependent spliceosomesCharacterization of U6 snRNA-protein interactions.The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPExtended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionRNA helicases in splicingCrystal structure of the functional domain of the splicing factor Prp18Structure and function of an RNase H domain at the heart of the spliceosomeProteins interacting with Lin 1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in Saccharomyces cerevisiae.Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Inhibition of a spliceosome turnover pathway suppresses splicing defects.Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae.The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae.Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors.Central region of the human splicing factor Hprp3p interacts with Hprp4pDomain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assemblyIdentification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing.Rearrangements within human spliceosomes captured after exon ligation.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Splicing enhancement in the yeast rp51b intron.Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release.Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.Role of Cwc24 in the First Catalytic Step of Splicing and Fidelity of 5' Splice Site Selection.Genetics and biochemistry remain essential in the structural era of the spliceosome.Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing.Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing.
P2860
Q22003972-7FC01142-7722-4782-BBBE-9305EDCE925AQ24306801-5904EFEC-8FB6-4A76-8EA0-9893A51F4521Q24320312-B6A53675-A35B-46FE-B475-C1C4B1A2C0FEQ24537200-0119C4E0-1769-4962-87D0-1DE8C293C642Q24537373-6214E0F7-7D29-4751-9993-02D03848B17FQ24539289-0F39D4F3-29FF-4847-B85E-FBD2063B002CQ24539330-AD3CA117-CF86-48EB-A6DA-0B13023FAD06Q24539395-F44B5A8E-3709-416E-B3D9-6CDC5AF932C5Q24539483-966EEDD9-B553-44AC-8DD2-9D7763A1AE8AQ24548787-981802CC-55A2-4C34-BBA8-FB92708B4CBBQ24812684-5B7AD9CC-A419-4947-81DB-767A69C2EB66Q27000261-C0071750-5956-4C4E-9E64-24DA89560755Q27621902-4B0EDF5D-D444-4C8A-B56F-148FACA32C70Q27652459-34C2519A-70A7-4651-9EE0-A3912E16465AQ27929851-F2CBA0C8-FEF6-4979-9AD5-D8B32E2005E0Q27930100-C9582D69-488F-4306-A726-6732471CAE47Q27933500-6137F0E3-AB92-41C2-9ADF-313CBDB9AC68Q27934423-75A958D9-1B37-484E-A4E2-354E2C6A5DA0Q27934735-310E84BE-B64F-470B-A83E-96C1C1449083Q27937416-19A97321-6764-4C99-951D-2C407EAEDF4AQ27937488-62986E6A-06E7-430C-BA32-BDF66D9DA070Q27937892-389FA24E-310F-41A1-B933-D71107A37831Q27937907-A522BB7C-C7AA-4B39-B3BA-98D54DBB1786Q27939548-1ABBC5E3-305E-4A8E-80C4-B6CF7EF2893AQ28215626-6432D6B1-1521-4977-AC26-FBBF6B7D17A3Q28284343-5A425128-51AB-4C83-AF97-DE36AD000748Q33887127-541CFFA8-6480-4C7A-8422-0910789898F4Q34324094-F8BF396F-95DB-4355-AEC9-88E5E44A880DQ34362402-AE1130DE-4E40-4693-AF4A-9D4DF2BAA316Q34362457-27F71638-3F01-4BD9-991C-369096D6EADEQ34486872-F32661F8-1DFC-497F-92A2-CEB3F0847EF6Q34610216-C4DB7E96-5F8A-454D-94A2-F18642F5CA5BQ34767752-BB663203-920B-4591-8646-15EF120AA329Q34788134-A0F55641-8E69-4C06-8E13-6673A2642EFFQ38294598-B1AFADC9-26CC-4C46-9608-986C5F6E4547Q39085957-D38DD7B3-910B-49C1-8870-8A0A8A76E2B1Q39108397-871FC52D-C5BF-42BE-8C3C-CB5E78FA295FQ39446580-CDFB6A61-82F2-48A1-B270-0B7DC5C6D3BBQ39698187-0A03D66F-3F16-4A38-92FB-159FD908F21BQ40789125-E2EF7FC2-EEC3-4EF2-B181-09C5C06336E1
P2860
Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Interaction of the yeast splic ...... during both steps of splicing.
@en
type
label
Interaction of the yeast splic ...... during both steps of splicing.
@en
prefLabel
Interaction of the yeast splic ...... during both steps of splicing.
@en
P2093
P2860
P356
P1476
Interaction of the yeast splic ...... during both steps of splicing.
@en
P2093
Teigelkamp S
Whittaker E
P2860
P304
P356
10.1093/NAR/23.3.320
P577
1995-02-01T00:00:00Z