The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome
about
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distributionPurification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicasesStructural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particlesPrp8 protein: at the heart of the spliceosomeThe canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosomeThe human Prp8 protein is a component of both U2- and U12-dependent spliceosomesThe molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factorsA mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 proteinA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionThe human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzymeCloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae.The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.A novel 40S multi-snRNP complex isolated from rat liver nucleiThree novel functional variants of human U5 small nuclear RNARIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins.Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals.Protein composition of mammalian spliceosomes assembled in vitroMutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection.The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RNA splicing with cell cycle progression.Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNADirect interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assemblyAn ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Affinity purification of spliceosomes reveals that the precursor RNA processing protein PRP8, a protein in the U5 small nuclear ribonucleoprotein particle, is a component of yeast spliceosomes.Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.Probing of the spliceosome with site-specifically derivatized 5' splice site RNA oligonucleotidesThe 5' end domain of U2 snRNA is required to establish the interaction of U2 snRNP with U2 auxiliary factor(s) during mammalian spliceosome assembly.Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing.Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts.The yeast PRP8 protein interacts directly with pre-mRNA.Three protein factors (SF1, SF3 and U2AF) function in pre-splicing complex formation in addition to snRNPsSplicing factor SF4 is dispensable for the assembly of a functional splicing complex and participates in the subsequent steps of the splicing reaction.Roles of PRP8 protein in the assembly of splicing complexes.
P2860
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P2860
The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome
description
1989 nî lūn-bûn
@nan
1989 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
The mammalian analogue of the ...... n particle and the spliceosome
@ast
The mammalian analogue of the ...... n particle and the spliceosome
@en
The mammalian analogue of the ...... n particle and the spliceosome
@nl
type
label
The mammalian analogue of the ...... n particle and the spliceosome
@ast
The mammalian analogue of the ...... n particle and the spliceosome
@en
The mammalian analogue of the ...... n particle and the spliceosome
@nl
prefLabel
The mammalian analogue of the ...... n particle and the spliceosome
@ast
The mammalian analogue of the ...... n particle and the spliceosome
@en
The mammalian analogue of the ...... n particle and the spliceosome
@nl
P2860
P356
P1476
The mammalian analogue of the ...... n particle and the spliceosome
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.22.8742
P407
P577
1989-11-01T00:00:00Z