Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
about
Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactionsRole of platelets in neuroinflammation: a wide-angle perspectivePharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist.alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors2D binary QSAR modeling of LPA3 receptor antagonism.LPA receptor signaling: pharmacology, physiology, and pathophysiology.Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogsATX-LPA receptor axis in inflammation and cancer.Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecenyl thiophosphate (OTP) in monkeys.Aiming drug discovery at lysophosphatidic acid targets.Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acidPhysiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification4-Trifluoromethyl-substituted coumarins with large Stokes shifts: synthesis, bioconjugates, and their use in super-resolution fluorescence microscopy.Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxinMitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acidChemical evolution of autotaxin inhibitorsVinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivoInhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid.The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasisBenzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.The tumor microenvironment: key to early detection.CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis.Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.Therapeutic potential of autotaxin/lysophospholipase d inhibitors.Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.Structure-based drug design identifies novel LPA3 antagonists.Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.Lysophosphatidic acid-1-receptor targeting agents for fibrosis.Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.Design of anticancer lysophosphatidic acid agonists and antagonists.Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptorsFarnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPALysophosphatidic acid receptor agonists and antagonists (WO2010051053).Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.Metal-free electrophilic phosphination of electron-rich arenes, arenols and aromatic thiols with diarylphosphine oxides.
P2860
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P2860
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Synthesis, structure-activity ...... , and inhibitors of autotaxin.
@en
type
label
Synthesis, structure-activity ...... , and inhibitors of autotaxin.
@en
prefLabel
Synthesis, structure-activity ...... , and inhibitors of autotaxin.
@en
P2093
P50
P356
P1476
Synthesis, structure-activity ...... a, and inhibitors of autotaxin
@en
P2093
Duane D Miller
Gabor Tigyi
Gangadhar G Durgam
Michelle D Walker
Nicole Wilke
Ryoko Tsukahara
Tamas Virag
Wolfgang Siess
Wouter H Moolenaar
P304
P356
10.1021/JM049609R
P407
P577
2005-07-01T00:00:00Z