Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.
about
Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells.Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathwaysDiagnostic and clinical relevance of the autophago-lysosomal network in human gliomasIFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosisBortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway.Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenograftsABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 CellsThe potential of proteasome inhibition in the treatment of colon cancer.Proteasome inhibitors: antitumor effects and beyond.Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region.BCL-2 family regulation by the 20S proteasome inhibitor bortezomib.From cancer immunosurveillance to cancer immunotherapy.The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis.Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway.Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibodyEnzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines.Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link.Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.
P2860
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P2860
Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Cooperative cytotoxicity of pr ...... nt Bcl-2-overexpressing cells.
@en
type
label
Cooperative cytotoxicity of pr ...... nt Bcl-2-overexpressing cells.
@en
prefLabel
Cooperative cytotoxicity of pr ...... nt Bcl-2-overexpressing cells.
@en
P2093
P1476
Cooperative cytotoxicity of pr ...... ant Bcl-2-overexpressing cells
@en
P2093
Alessio Nencioni
Claus Belka
Davide Boy
Franco Patrone
Gabriella Cirmena
Giovanna Dal Bello
Lucia Wille
Peter Brossart
P304
P356
10.1158/1078-0432.CCR-04-2496
P407
P577
2005-06-01T00:00:00Z