Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.
about
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis.Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K.Identification of mutations in distinct regions of p85 alpha in urothelial cancer.Novel functions for Rab GTPases in multiple aspects of tumour progression.Caspase 8 promotes peripheral localization and activation of Rab5.Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemiaRole of p85α in neutrophil extra- and intracellular reactive oxygen species generation.Genomic amplicons target vesicle recycling in breast cancer.Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis.Vinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expressionActivation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.The secret life of kinases: functions beyond catalysisAbrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase.Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.
P2860
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P2860
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
Disrupted RabGAP function of t ...... esults in cell transformation.
@en
type
label
Disrupted RabGAP function of t ...... esults in cell transformation.
@en
prefLabel
Disrupted RabGAP function of t ...... esults in cell transformation.
@en
P2093
P2860
P356
P1476
Disrupted RabGAP function of t ...... results in cell transformation
@en
P2093
Andrea D Hawrysh
Anurag Saxena
Deborah H Anderson
Jennifer C Oberg
Kristy M James
P2860
P304
15861-15868
P356
10.1074/JBC.M800941200
P407
P577
2008-04-03T00:00:00Z