A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
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Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.COPASAAR--a database for proteomic analysis of single amino acid repeats.Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutationThe Protein Structure Context of PolyQ RegionsAtaxin-1 fusion partners alter polyQ lethality and aggregation.Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers.Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionOligonucleotide-based strategies to combat polyglutamine diseases.Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.A compact beta model of huntingtin toxicity.Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophyIdentification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and propertiesStructural features and domain organization of huntingtin fibrils.Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxiaAn Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal ModelHuntingtin associated protein 1 and its functions.Protein aggregates in Huntington's disease.An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicityPolyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates.The challenge in translating basic research discoveries to treatment of Huntington disease.Architecture of polyglutamine-containing fibrils from time-resolved fluorescence decay.The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.Biophysical Aspect of Huntingtin Protein During polyQ: An In Silico Insight.Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain.Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic.Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin.Hydrogels from amphiphilic star block copolypeptides
P2860
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P2860
A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A structure-based analysis of ...... compact beta-sheet structure.
@en
type
label
A structure-based analysis of ...... compact beta-sheet structure.
@en
prefLabel
A structure-based analysis of ...... compact beta-sheet structure.
@en
P356
P1476
A structure-based analysis of ...... compact beta-sheet structure.
@en
P2093
Haibing Jiang
Michelle A Poirier
P304
P356
10.1093/HMG/DDI071
P577
2005-02-02T00:00:00Z