Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.
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Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificitiesStructural model for deoxycytidine deamination mechanisms of the HIV-1 inactivation enzyme APOBEC3GRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesPolymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblastsAnalysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityModels of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.Modelling mutational landscapes of human cancers in vitro.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNAAID and somatic hypermutation.The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain.Mechanism and regulation of class switch recombinationRecombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cellsIndividual substitution mutations in the AID C terminus that ablate IgH class switch recombination.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasSingle-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.A Public Database of Memory and Naive B-Cell Receptor SequencesUNG shapes the specificity of AID-induced somatic hypermutation.AID to overcome the limitations of genomic information.A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutantsActivation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repairInducible DNA breaks in Ig S regions are dependent on AID and UNGRegulation of AID, the B-cell genome mutator.DNA translocation by human uracil DNA glycosylase: the case of single-stranded DNA and clustered uracils.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsClass switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.Multiple transcription factor binding sites predict AID targeting in non-Ig genes
P2860
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P2860
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Biochemical analysis of hyperm ...... on-induced cytidine deaminase.
@en
type
label
Biochemical analysis of hyperm ...... on-induced cytidine deaminase.
@en
prefLabel
Biochemical analysis of hyperm ...... on-induced cytidine deaminase.
@en
P2093
P356
P1476
Biochemical analysis of hyperm ...... on-induced cytidine deaminase.
@en
P2093
Myron F Goodman
Peter Calabrese
Phuong Pham
Ronda Bransteitter
P304
51612-51621
P356
10.1074/JBC.M408135200
P407
P577
2004-09-14T00:00:00Z