DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
about
IgH chain class switch recombination: mechanism and regulationMutation of POLB causes lupus in miceATAD5 deficiency decreases B cell division and Igh recombinationRefining the Neuberger model: Uracil processing by activated B cells.AID and somatic hypermutation.Mechanism and regulation of class switch recombinationXRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.p53 represses class switch recombination to IgG2a through its antioxidant functionParp3 negatively regulates immunoglobulin class switch recombination.X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phaseDoes DNA repair occur during somatic hypermutation?APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.DNA polymerases in adaptive immunity.Hijacked DNA repair proteins and unchained DNA polymerases.Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switchRestricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylaseDNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching.Heat shock protein 70 (Hsp70)-stimulated deoxycytidine deaminases from a human lymphoma cell but not the activation-induced cytidine deaminase (AID) from Ramos 6.4 human Burkitt's lymphoma cells.Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombinationActivation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.
P2860
Q27001131-F8810309-2D3D-43D9-BD29-35FE263D4DFDQ28513579-64B8AB19-475F-4EE6-9A44-3D040C766ADBQ28592936-E11F9A05-5C1D-49D8-B534-5E0652E2BD41Q34018586-C5437BD3-3F30-4A67-9771-39189D075FA9Q34118000-11D9B509-8F85-48E2-8260-F4FED3C9468AQ34764888-7FEA669A-06A1-42FB-9AE8-4B9F9E335ED7Q35441496-8F41E710-A0C1-418F-BBFB-D77CA1A9699EQ35606409-CF0224FF-C59D-4CEC-8BA1-8CA2B05F6C2DQ35637214-3E209F70-19CD-445A-826C-EC5F4AB55AFEQ35849574-50E47A18-3CA9-45AC-B3F7-E60F2474FB69Q35946097-C8DE89F3-8E76-4AF4-864A-55FE19937DC4Q36173864-2595F70D-ABB6-4DAF-A650-7042FEFFA6AEQ36229211-7034E60B-2779-40C4-A983-292A5CDFF54BQ36661484-C5441010-8007-46DE-A91C-DBC38170D8CEQ36853393-277675F6-E38B-4FC3-92BC-2AB1BAE3D729Q36923850-A21D7411-22A1-4A2B-B9F5-695BB0B941F4Q36945144-CD634BAE-9B30-4CE7-9C5F-A7C2022B4048Q37109944-AFFBF89C-D261-4C00-9741-DEE88D9B23AAQ37140473-1D11D4BA-9694-4869-B768-E305C8DF973FQ37164431-29D8DBEF-99AC-4C95-85AA-9A4EBE9A2E0DQ37326089-6B95C379-8FDB-497C-AC9C-0339E80674D1Q37419452-72A5630D-110C-4839-A5AF-76024D99C4DDQ37507628-DEFD1416-0DA1-4023-B23B-BFE3D9A0E408Q37659751-E3F0B8A6-E039-4B63-9CF7-7801883BC012Q37724828-2A2A6038-8278-416D-9DCE-3D02E74D8BC5Q39033272-AD6A8CA2-B86D-46C7-A23A-1E5004817863Q39672369-8D15D53B-472F-4AC5-8145-73E6CC0ABB32Q40587292-6A287F1C-32F0-4753-9346-FBF323EA1819Q41661129-D6D258B3-AFC5-40A1-AC12-46C490AF6127Q41887653-1D81A9E5-44CF-4ACA-A199-6316ABF5B2C6Q41999588-949E114E-20FC-43BF-A017-51635BBC9FC2Q42630118-88D3A8AC-26E2-4F3F-9B48-46638E47CD3B
P2860
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
DNA polymerase beta is able to ...... in class switch recombination.
@ast
DNA polymerase beta is able to ...... in class switch recombination.
@en
type
label
DNA polymerase beta is able to ...... in class switch recombination.
@ast
DNA polymerase beta is able to ...... in class switch recombination.
@en
prefLabel
DNA polymerase beta is able to ...... in class switch recombination.
@ast
DNA polymerase beta is able to ...... in class switch recombination.
@en
P2860
P356
P1476
DNA polymerase beta is able to ...... in class switch recombination.
@en
P2093
Janet Stavnezer
Xiaoming Wu
P2860
P304
P356
10.1084/JEM.20070756
P407
P577
2007-06-25T00:00:00Z