Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. - Wikidata - awgldk - TriplyDB

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

http://www.wikidata.org/entity/Q40523976

about

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling Gastrointestinal stem cells in health and disease: from flies to humans Targeting Notch to overcome radiation resistance Lineage selection and plasticity in the intestinal crypt Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis Notch signaling in stomach epithelial stem cell homeostasis Direct regulation of intestinal fate by Notch Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer's disease models Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.Modeling an anti-amyloid combination therapy for Alzheimer's disease.Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development During Xenopus Laevis Metamorphosis.Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.Notch: architect, landscaper, and guardian of the intestine.Mammary development and breast cancer: the role of stem cells Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.The canonical Notch signaling was involved in the regulation of intestinal epithelial cells apoptosis after intestinal ischemia/reperfusion injury.Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.Delta-like ligand 4 (Dll4) predicts the prognosis of clear cell renal cell carcinoma, and anti-Dll4 suppresses tumor growth in vivo.Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation.The Role of the Notch Signal Pathway in Mucosal Cell Metaplasia in Mouse Acute Otitis Media.NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer's disease: the DARAD trial.Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells.Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation Targeting Notch Signaling in Colorectal Cancer.

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

http://www.wikidata.org/entity/Q40523976

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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Modulation of notch processing ...... etory lineage differentiation.

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Modulation of notch processing ...... etory lineage differentiation.

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Modulation of notch processing ...... etory lineage differentiation.

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Toxicological Sciences

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Modulation of notch processing ...... etory lineage differentiation.

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Anna Zacco

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Barry Greenberg

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Claude Dagenais

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Francois Pognan

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Jenny McKay

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Joseph Milano

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Linda Foster-Brown

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Paul J Ciaccio

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Reto Gadient

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Robert T Jacobs

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341-358

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10.1093/TOXSCI/KFH254

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1

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2004-08-19T00:00:00Z

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8393089

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15319485

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