Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
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N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adductsOverview of base excision repair biochemistryGenetic markers and biomarkers for age-related macular degeneration.Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues.Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient miceATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance.Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predispositionEnzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer riskAlkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patientsRemoval of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.Base excision repair activities differ in human lung cancer cells and corresponding normal controls.N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cellsN-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaksKnockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthBalancing repair and tolerance of DNA damage caused by alkylating agentsPersistent damage induces mitochondrial DNA degradation.DNA repair proteins as molecular targets for cancer therapeutics.Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents.Molecular pathology of age-related macular degenerationSmall interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress.Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation.Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.DNA Damage, DNA Repair, Aging, and NeurodegenerationAP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts.Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β.Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons.Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies.
P2860
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P2860
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Transient adenoviral N-methylp ...... to human breast cancer cells.
@en
type
label
Transient adenoviral N-methylp ...... to human breast cancer cells.
@en
prefLabel
Transient adenoviral N-methylp ...... to human breast cancer cells.
@en
P2093
P921
P1476
Transient adenoviral N-methylp ...... to human breast cancer cells.
@en
P2093
David Caldwell
Mark R Kelley
Mikael Rinne
P304
P577
2004-08-01T00:00:00Z