Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
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IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expressionOnto better TRAILs for cancer treatmentAntimitotic drugs in the treatment of cancerMarine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)Following a TRAIL: update on a ligand and its five receptorsBid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effectsCharacterizing the relationship between steady state and response using analytical expressions for the steady states of mass action modelsModulating cell-to-cell variability and sensitivity to death ligands by co-drugging.Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers.TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibBortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathwaysSrc kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppressionNon-invasive fluorescence imaging of cell death in fresh human colon epithelia treated with 5-Fluorouracil, CPT-11 and/or TRAIL.TRAIL in cancer therapy: present and future challenges.The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt.Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis.Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B.Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells.Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase.Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC levelRegulating TRAIL receptor-induced cell death at the membrane : a deadly discussionTargeted ovarian cancer treatment: the TRAILs of resistance.WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis.Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivoDR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.Following the TRAIL from hepatitis C virus and alcohol to fatty liverSurveillance of spontaneous breast cancer metastasis by TRAIL-expressing CD34⁺ cells in a xenograft modelc-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effectsNotch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expressionApoptosis and necrosis in the liverTRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies.
P2860
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P2860
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Enhanced caspase-8 recruitment ...... sis by chemotherapeutic drugs.
@en
type
label
Enhanced caspase-8 recruitment ...... sis by chemotherapeutic drugs.
@en
prefLabel
Enhanced caspase-8 recruitment ...... sis by chemotherapeutic drugs.
@en
P2093
P2860
P50
P356
P1476
Enhanced caspase-8 recruitment ...... osis by chemotherapeutic drugs
@en
P2093
A Grosse-Wilde
M A Weigand
P H Krammer
T M Ganten
P2860
P2888
P304
P356
10.1038/SJ.CDD.4401437
P478
11 Suppl 1
P577
2004-07-01T00:00:00Z
P5875
P6179
1044829246