Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
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Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathwayMyocilin is a modulator of Wnt signalingDifferential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowthSecretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP)Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosageTyro3 Modulates Mertk-Associated Retinal DegenerationInteraction between two glaucoma genes, optineurin and myocilinThe Optimedin gene is a downstream target of Pax6Myocilin interacts with syntrophins and is member of dystrophin-associated protein complexZebrafish olfactomedin 1 regulates retinal axon elongation in vivo and is a modulator of Wnt signaling pathway.Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones.Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesisGenes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma.Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells.Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Transgenic mice expressing mutated Tyr437His human myocilin develop progressive loss of retinal ganglion cell electrical responsiveness and axonopathy with normal iop.Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells.Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis.Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell linesThe effect of temperature on gene silencing by siRNAs: implications for silencing in the anterior chamber of the eye.Generation of Cre transgenic mice with postnatal RPE-specific ocular expressionSequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma.Pro370Leu myocilin mutation in a Chinese pedigree with juvenile-onset open angle glaucoma.The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease.Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.Cellular processing of myocilin.Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.Structural basis for misfolding in myocilin-associated glaucoma.Celastrol supports survival of retinal ganglion cells injured by optic nerve crush.Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis).Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.Comprehensive analysis of myocilin variants in east Indian POAG patients.Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells
P2860
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P2860
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
@en
type
label
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
@en
prefLabel
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
@en
P2860
P356
P1476
Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.
@en
P2093
Douglas Vollrath
P2860
P304
P356
10.1093/HMG/DDH128
P577
2004-04-06T00:00:00Z