Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts - Wikidata - awgldk - TriplyDB

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

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How HIV takes advantage of the cytoskeleton in entry and replication Lipids and membrane microdomains in HIV-1 replication A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42 "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way.HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection Characterization of Lassa virus glycoprotein oligomerization and influence of cholesterol on virus replication.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef The Role of Lipids in Retrovirus Replication.The SCHOOL of nature: III. From mechanistic understanding to novel therapies The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance Coordinating cytoskeletal tracks to polarize cellular movements Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.Subcellular targeting of oxidants during endothelial cell migration The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity.Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef.Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development Genomics of pulmonary arterial hypertension: implications for therapy.Viral infection and pulmonary hypertension: is there an association?Functional roles for myosin 1c in cellular signaling pathways.Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts.PAK in pathogen-host interactions.The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.Impaired neurotransmission in ether lipid-deficient nerve terminals Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.

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P2860

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

http://www.wikidata.org/entity/Q40572781

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2004 nî lūn-bûn

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2004年論文

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2004年论文

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name

Human immunodeficiency virus t ...... a recruitment into lipid rafts

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Human immunodeficiency virus t ...... a recruitment into lipid rafts

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Human immunodeficiency virus t ...... a recruitment into lipid rafts

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JVI.78.8.4085-4097.2004

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Journal of Virology

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Human immunodeficiency virus t ...... a recruitment into lipid rafts

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Ellen Krautkrämer

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Judith E Gasteier

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Simone I Giese

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Walter Muranyi

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P2860

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

Identification of the Nef-associated kinase as p21-activated kinase 2

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Structure--function relationships in HIV-1 Nef.

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

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4085-4097

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10.1128/JVI.78.8.4085-4097.2004

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8

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Oliver T Fackler

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8652695

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374280

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