Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration.
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Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in modelMouse models of polyglutamine diseases: review and data table. Part IPathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophyAutophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceOpposing effects of polyglutamine expansion on native protein complexes contribute to SCA1Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapyProtein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophySecond cistron in CACNA1A gene encodes a transcription factor mediating cerebellar development and SCA6Androgen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.Therapeutic approaches to spinal and bulbar muscular atrophyMicroarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophyEndoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapyAnimal models of Kennedy disease.Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophyAndrogen receptor and Kennedy disease/spinal bulbar muscular atrophyPhysical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence.Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapyRecovery of function in a myogenic mouse model of spinal bulbar muscular atrophy.Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expressionInsulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophyAbsence of disturbed axonal transport in spinal and bulbar muscular atrophy.Motor neuron trophic factors: therapeutic use in ALS?Transcriptional profile of muscle following acute induction of symptoms in a mouse model of Kennedy's disease/spinobulbar muscular atrophy.Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice.Restoration of spermatogenesis and male fertility using an androgen receptor transgene.Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy.Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action.Human adipose-derived mesenchymal stem cells as a new model of spinal and bulbar muscular atrophy.Androgen-dependent loss of muscle BDNF mRNA in two mouse models of SBMA.Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6.Vascular endothelial growth factor and the nervous system.Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
P2860
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P2860
Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Androgen receptor YAC transgen ...... the motor neuron degeneration.
@en
type
label
Androgen receptor YAC transgen ...... the motor neuron degeneration.
@en
prefLabel
Androgen receptor YAC transgen ...... the motor neuron degeneration.
@en
P2093
P1433
P1476
Androgen receptor YAC transgen ...... the motor neuron degeneration.
@en
P2093
Albert R La Spada
Bryce L Sopher
Carol B Ware
Ida E Holm
Lee-Way Jin
Lisa M Ellerby
Michelle A LaFevre-Bernt
Patrick S Thomas
Randell T Libby
Scott A Wilke
P304
P356
10.1016/S0896-6273(04)00082-0
P407
P577
2004-03-01T00:00:00Z