p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
about
Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicityp66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosisThe small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesisReactive oxygen species (ROS) homeostasis and redox regulation in cellular signalingDistinct signaling functions for Shc isoforms in the heartAntagonism of p66shc by melanoma inhibitory activity.The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.P66Shc signals to age.Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.Selective inhibition of protein kinase C β2 attenuates the adaptor P66 Shc-mediated intestinal ischemia-reperfusion injuryCRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cellsERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cellsP66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgeneThe influence of Shc proteins on life span in mice.Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.Mitochondrial longevity pathwaysDecoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling.D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc.Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signalingRegulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of AktChronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc.p66Shc-generated oxidative signal promotes fat accumulationp66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 memDevelopmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humansA novel role of Shc adaptor proteins in steroid hormone-regulated cancers.Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells.The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells.Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells.Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets.p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress.
P2860
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P2860
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
@en
type
label
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
@en
prefLabel
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
@en
P2093
P2860
P50
P1476
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells
@en
P2093
Cosima T Baldari
Cristina Ulivieri
Enrica Migliaccio
Michela Pellegrini
Piergiuseppe Pelicci
Sonia Pacini
P2860
P304
P356
10.1128/MCB.24.4.1747-1757.2004
P407
P577
2004-02-01T00:00:00Z