The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.
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A Temporal Model of Human IgE and IgG Antibody FunctionIgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation processCorrelation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies.Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphadenopathyB lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selectionDiversity and repertoire of IgW and IgM VH families in the newborn nurse sharkImmunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell LymphomaClonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemiaImmunoglobulin VH-gene usage of autoantibodies in mercuric chloride-induced membranous glomerulopathy in the ratQuantifying evolutionary constraints on B-cell affinity maturationGetting started in computational immunologyMolecular analysis of HIV-1 gp120 antibody response using isotype IgM and IgG phage display libraries from a long-term non-progressor HIV-1-infected individual.The role of somatic mutation in determining the affinity of anti-DNA antibodies.Analysis of Ig kappa light chain gene variable regions expressed in the rheumatoid synovial B cells.Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation.Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection.Analysis of VH gene sequences using two web-based immunogenetics resources gives different results, but the affinity maturation status of chronic lymphocytic leukaemia clones as assessed from either of the resulting data sets has no prognostic signiSingle cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions.CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes.Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritisDifferent Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis.CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoire.BCL-6 in the pathogenesis of non-Hodgkin's lymphoma.E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.Somatic hypermutation and B-cell lymphoma.Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.Quantifying selection in high-throughput Immunoglobulin sequencing data setsImmunoglobulin variable-region gene usage in systemic autoimmune diseases.T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V(H) gene mutation status.Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome.Malignant B cells and antigenic receptor: necessity or habit?Evidence of canonical somatic hypermutation in hairy cell leukemiaSystematic analysis of sequences of anti-DNA antibodies--relevance to theories of origin and pathogenicity.Detecting selection in immunoglobulin sequencesLupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variationB cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regionsImmunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Defining the recognition elements of Lewis Y-reactive antibodies.
P2860
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P2860
The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The CDR1 sequences of a major ...... ble to amino acid replacement.
@en
type
label
The CDR1 sequences of a major ...... ble to amino acid replacement.
@en
prefLabel
The CDR1 sequences of a major ...... ble to amino acid replacement.
@en
P2860
P1433
P1476
The CDR1 sequences of a major ...... ble to amino acid replacement.
@en
P2093
P2860
P304
P356
10.1016/0167-5699(94)90175-9
P577
1994-08-01T00:00:00Z