The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in miceStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 MutationMolecular mechanism for a role of SHP2 in epidermal growth factor receptor signalingA place for precision medicine in bladder cancer: targeting the FGFRs.Novel phosphotyrosine targets of FGFR2IIIb signaling.Molecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC)Biology of urothelial tumorigenesis: insights from genetically engineered mice.Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumorsFGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancerThe Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cellsPalifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models.SHP2E76K mutant promotes lung tumorigenesis in transgenic miceMolecular Mechanisms that Regulate Epidermal Growth Factor Receptor InactivationTargeting protein tyrosine phosphatases for anticancer drug discovery.Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR.Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.Functions of Shp2 in cancer.Urothelial tumorigenesis: a tale of divergent pathways.Protein-tyrosine phosphatases and cancer.HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling.Grb2, a double-edged sword of receptor tyrosine kinase signalingThe tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migrationMolecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner.Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins.Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CAActivated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CAActivated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
P2860
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P2860
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The phosphotyrosine phosphatas ...... last growth factor receptor 3.
@en
type
label
The phosphotyrosine phosphatas ...... last growth factor receptor 3.
@en
prefLabel
The phosphotyrosine phosphatas ...... last growth factor receptor 3.
@en
P2093
P2860
P356
P1433
P1476
The phosphotyrosine phosphatas ...... last growth factor receptor 3.
@en
P2093
Irene Ischenko
Michael J Hayman
Nieves Movilla
Yehenew M Agazie
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206798
P407
P577
2003-10-01T00:00:00Z
P5875
P6179
1040464757