Differential ubiquitination defines the functional status of the tumor suppressor Smad4. - Wikidata - awgldk - TriplyDB

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

http://www.wikidata.org/entity/Q40641509

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HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3 Recombination-activating gene proteins: more regulation, please Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting Smad4-expression is decreased in breast cancer tissues: a retrospective study.Mining the TRAF6/p62 interactome for a selective ubiquitination motif.Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics.Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.Hippo pathway phylogenetics predicts monoubiquitylation of Salvador and Merlin/Nf2 Ubiquitin-dependent regulation of TGFbeta signaling in cancer SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry.Non-degradative ubiquitination in Smad-dependent TGF-β signaling Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.Ubiquitin and proteasomes in transcription Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas.Regulating the stability of TGFbeta receptors and Smads.Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2 Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection.Informatics approaches to understanding TGFbeta pathway regulation.Degradation of activated protein kinases by ubiquitination.Proteomic identification of protein ubiquitination events.SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan Regulation of TGF-beta signalling by protein phosphatases.Role of Smads in TGFβ signaling.Post-translational regulation of TGF-β receptor and Smad signaling.New insights into extracellular and post-translational regulation of TGF-β family signalling pathways.The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling Reverse correlation of Jab1 and Smad4 in PANC-1 cells involved in the pathogenesis of pancreatic cancer Berbamine enhances the antineoplastic activity of gemcitabine in pancreatic cancer cells by activating transforming growth factor-β/Smad signaling.Transforming Growth Factor-β1 Modulates the Expression of Syndecan-4 in Cultured Vascular Endothelial Cells in a Biphasic Manner.

P2860

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P2860

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

http://www.wikidata.org/entity/Q40641509

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

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type

label

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

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prefLabel

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

@en

P1433

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Journal of Biological Chemistry

P1476

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

@en

P2093

Anita Morén

http://www.w3.org/2001/XMLSchema#string

Aristidis Moustakas

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Carl-Henrik Heldin

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Takeshi Imamura

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Ulf Hellman

http://www.w3.org/2001/XMLSchema#string

Yuri Inada

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Structural basis of Smad1 activation by receptor kinase phosphorylation

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

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10.1074/JBC.M300159200

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35

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278

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protein ubiquitination