Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.
about
RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolismParkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityLeucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Parkin mono-ubiquitinates Bcl-2 and regulates autophagyParkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell deathLoss of association of REEP2 with membranes leads to hereditary spastic paraplegiaParkin is recruited selectively to impaired mitochondria and promotes their autophagyThe kinase domain of mitochondrial PINK1 faces the cytoplasmPINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsParkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicityThe Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP SynthaseElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsMitochondrial biology and Parkinson's diseaseMolecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionPINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's diseasePathologic and therapeutic implications for the cell biology of parkinMitochondrial dysfunction and oxidative stress in Parkinson's diseaseTissue- and cell-specific mitochondrial defect in Parkin-deficient miceA molecular explanation for the recessive nature of parkin-linked Parkinson’s diseaseCeramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ AccumulationMolecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutantL166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome systemEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Parkin is protective against proteotoxic stress in a transgenic zebrafish modelParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinMitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinPINK1-dependent recruitment of Parkin to mitochondria in mitophagy.MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network.The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.
P2860
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P2860
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Parkin prevents mitochondrial ...... chondria-dependent cell death.
@en
type
label
Parkin prevents mitochondrial ...... chondria-dependent cell death.
@en
prefLabel
Parkin prevents mitochondrial ...... chondria-dependent cell death.
@en
P2093
P50
P356
P1476
Parkin prevents mitochondrial ...... ochondria-dependent cell death
@en
P2093
Alexis Brice
Christoph B Lücking
Cornelia Hampe
Marie-Paule Muriel
Merle Ruberg
Nacer Abbas
Thomas Rooney
Wen-Jie Gu
P304
P356
10.1093/HMG/DDG044
P577
2003-03-01T00:00:00Z