Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.
about
Melanoma: from melanocyte to genetic alterations and clinical optionsGpnmb is a melanoblast-expressed, MITF-dependent geneClinical significance of BRAF mutations in metastatic melanomaPrimary malignant mucosal melanoma of the upper lip: a case report and review of the literatureTargeting NADPH oxidases for the treatment of cancer and inflammationFrequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis.Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformationMEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells.Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survivalOverexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB.Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses.Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo.Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma.Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma.Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.Associations between environmental factors and incidence of cutaneous melanoma. ReviewThe p38 MAPK stress pathway as a tumor suppressor or more?Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.Effects of bavachin and its regulation of melanin synthesis in A375 cellsHonokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivoApplication of angiogenesis to clinical dermatology.Current insights on the biology and clinical aspects of VEGF regulation.Targeting MAPK pathway in melanoma therapy.Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications.Metastatic pathways in patients with cutaneous melanoma.Tumor angiogenesis and vascular normalization: alternative therapeutic targets.Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation.Structure and regulation of the versican promoter: the versican promoter is regulated by AP-1 and TCF transcription factors in invasive human melanoma cells.Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells.Oral malignant melanoma: A report of two cases with BRAF molecular analysis.Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion.Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas.Intratumor and Intertumor Heterogeneity in Melanoma.Targeting the duality of cancer.BRAF and NRAS Mutations Are Frequent in Nodular Melanoma but Are not Associated with Tumor Cell Proliferation or Patient Survival
P2860
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P2860
Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Malignant transformation of me ...... nase kinase (MAPKK) signaling.
@en
type
label
Malignant transformation of me ...... nase kinase (MAPKK) signaling.
@en
prefLabel
Malignant transformation of me ...... nase kinase (MAPKK) signaling.
@en
P2093
P2860
P4510
P356
P1476
Malignant transformation of me ...... nase kinase (MAPKK) signaling.
@en
P2093
Baskaran Govindarajan
Cynthia Cohen
Gwendolyn Louis
Jack L Arbiser
Marsha Moses
Susan Kilroy
Xianhe Bai
P2860
P304
P356
10.1074/JBC.M212929200
P407
P577
2003-01-03T00:00:00Z